What is Linzess (Constella)?

Linzess, known as Constella in Canada, is a prescription medication used to treat:

• Irritable Bowel Syndrome with Constipation (IBS-C): Provides relief from abdominal pain and improves bowel movements.
• Chronic Idiopathic Constipation (CIC): Increases stool frequency and reduces straining.

The active ingredient, linaclotide, is a guanylate cyclase-C (GC-C) agonist that works locally in the intestines to increase fluid secretion, soften stools, and reduce abdominal pain. Linzess (Constella) is highly effective for patients who have not responded to traditional laxatives or other therapies.

Why Buy Linzess (Constella) from Canada?

For U.S. patients, purchasing Linzess (Constella) from Canada offers significant cost savings. Canadian pharmacies provide the same high-quality medication at regulated prices, making it a cost-effective solution for managing IBS-C and chronic constipation.

Cost Savings

By buying Linzess (Constella) from Canada, you can save up to 50% compared to U.S. pharmacy prices. For patients needing long-term treatment, this represents substantial savings on prescription costs.

Trusted Quality

Canadian pharmacies adhere to strict regulatory standards, ensuring the authenticity and quality of your medication. When you order from reputable providers, you can trust the safety and effectiveness of the product.

Coupons and Discounts

Finding the best deals on Linzess (Constella) is easier than you think when you take advantage of Linzess coupon codes and discounts offered by trusted Canadian pharmacies. Many pharmacies, including Over the Border Meds, provide promotional codes for first-time customers, helping you significantly reduce your expenses.

For example, you can use the coupon code Hello10 to get 10% off your first order of Linzess, making it even more affordable to manage your digestive health. These discounts are a fantastic way to save money, especially when compared to U.S. pharmacy prices.

Keep an eye out for seasonal promotions and referral bonuses that can stack additional savings on your order. By choosing a Canadian pharmacy, you’re already saving thanks to Canada’s regulated drug pricing, and combining that with a Linzess coupon code makes it an even smarter choice.

Remember, ordering Linzess from Canada is not only cost-effective but also convenient, with straightforward shipping to U.S. customers.

How Linzess (Constella) Works

Linaclotide, the active ingredient in Linzess (Constella), activates GC-C receptors in the intestinal lining. This action increases cyclic guanosine monophosphate (cGMP) levels, leading to:

• Increased intestinal fluid secretion.
• Improved stool consistency and frequency.
• Reduced abdominal pain by modulating pain-sensing nerves in the gut.

Unlike over-the-counter laxatives, Linzess (Constella) addresses the underlying causes of IBS-C and CIC, offering more comprehensive relief for patients.

Dosage and Administration

The recommended doses for Linzess (Constella) are:

• IBS-C: 290 mcg once daily, taken on an empty stomach at least 30 minutes before the first meal of the day.
• CIC: 145 mcg once daily, taken under the same conditions.

Swallow capsules whole without breaking or chewing them. Always follow your healthcare provider's dosing instructions to achieve optimal results.

Potential Side Effects

Common Side Effects:

• Diarrhea
• Abdominal pain
• Flatulence
• Headache

Serious Side Effects:

• Severe diarrhea leading to dehydration
• Allergic reactions such as rash or swelling

If you experience severe or persistent symptoms, discontinue use and contact your healthcare provider immediately.

Use in Pregnancy and Breastfeeding

Pregnancy: Linzess (Constella) should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor before starting treatment.

Breastfeeding: It is unknown if linaclotide is excreted in human milk. Breastfeeding mothers should consult their healthcare provider to weigh the benefits and risks.

Contraindications

• Known hypersensitivity to linaclotide or any other ingredients in the formulation.
• Patients under 6 years of age due to the risk of severe dehydration.
• Use in patients aged 6 to 18 years is not recommended.

Patients with a history of severe gastrointestinal obstruction should avoid using Linzess (Constella).

Foods to Avoid While Taking Linzess

When taking Linzess (Constella), certain foods may worsen digestive side effects like bloating, diarrhea, or discomfort. Here are some foods to avoid:

• High-Fat Foods: Greasy or fried foods can increase the risk of stomach upset and diarrhea.
• Spicy Foods: Dishes with chili, hot peppers, or strong spices may irritate your digestive system.
• Dairy Products: For those with lactose intolerance, milk, cheese, and other dairy items can worsen symptoms.
• Carbonated Beverages: Sodas and sparkling water can cause bloating and gas.
• Artificial Sweeteners: Sweeteners like sorbitol or aspartame may lead to increased digestive discomfort.

Sticking to a balanced, low-fat diet and drinking plenty of water can help minimize side effects and improve your experience with Linzess.

Alternative Options to Linzess (Constella)

While Linzess (Constella) is highly effective, some patients may explore alternative treatments for IBS-C and CIC, including:

• Amitiza (lubiprostone): Another prescription medication that increases fluid secretion in the intestines.
• Trulance (plecanatide): Works similarly to Linzess and may be an alternative for certain patients.
• Over-the-Counter Laxatives: While these may provide temporary relief, they do not address the underlying causes of IBS-C or CIC.

Discuss these options with your doctor to determine the best treatment for your condition.

Storage and Stability

• Temperature: Store at 20–25°C (68–77°F).
• Packaging: Keep the medication in its original container with the desiccant to protect from moisture.

Ensure the container is tightly closed and stored away from direct sunlight or heat.

FAQs About Linzess (Constella)

• What is the difference between Linzess and Constella? Linzess and Constella are the same medication; Constella is the brand name used in Canada.
• How does Linzess (Constella) work? It increases intestinal fluid secretion and reduces pain by activating GC-C receptors in the intestines.
• Can I buy Linzess (Constella) from Canada? Yes, it is available at trusted Canadian pharmacies at lower prices than in the U.S.
• What should I do if I miss a dose? Skip the missed dose and continue with your next scheduled dose. Do not double up.
• Is Linzess (Constella) safe during pregnancy? Consult your doctor as its use during pregnancy should be carefully evaluated.
• Are there alternatives to Linzess? Options like Amitiza and Trulance may be suitable alternatives.
• How long does it take for Linzess (Constella) to work? Many patients experience relief within the first week of treatment.
• Is Linzess (Constella) covered by insurance? Check with your insurance provider, as coverage may vary. Buying from Canada may still offer savings.
• Can Linzess (Constella) be taken long-term? Yes, it is often prescribed for long-term management of IBS-C and CIC.
• What are the storage requirements for Linzess (Constella)? Store at room temperature and keep it dry.

How to Order Linzess (Constella) from Canada

1. Consult Your Doctor: Obtain a valid prescription for Linzess (Constella).
2. Choose a Canadian Pharmacy: Select a reputable pharmacy that serves U.S. patients, such as Over the Border Meds.
3. Submit Your Prescription: Upload your prescription and complete the order process online.
4. Receive Your Medication: Your order will be delivered securely to your home.