Trulance (Plecanatide)

Trulance (Plecanatide)


Product information

Trulance (Plecanatide) is a medication used to treat chronic idiopathic constipation and irritable bowel syndrome with constipation in adults.

In stock and ready to ship.

RX Required

trulance generic

Trulance (Plecanatide) 

Trulance, with the active ingredient Plecanatide, is a prescription medication used to treat certain types of bowel disorders. It is primarily prescribed for chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults. Plecanatide is a guanylate cyclase-C agonist that works by increasing intestinal fluid secretion and transit, facilitating bowel movements.  


  • Chronic Idiopathic Constipation (CIC) in adults.
  • Irritable Bowel Syndrome with Constipation (IBS-C) in adults.

Dosage and Administration:

  • The recommended dose is 3 mg taken orally once daily, with or without food.
  • Tablets should be swallowed whole, not crushed or chewed.
  • For patients unable to swallow tablets, the tablet can be crushed and mixed with water or soft foods.


  • Patients under 6 years of age due to the risk of serious dehydration.
  • Patients with known or suspected mechanical gastrointestinal obstruction.


  • Use with caution in patients with severe renal impairment or severe hepatic impairment.
  • Avoid use in patients 6 years to less than 18 years of age.
  • Monitor for signs of excessive diarrhea or dehydration.

Side Effects:

Common side effects may include:
  • Diarrhea
  • Abdominal pain
  • Nausea
  • Headache
  • Increased gas
  • Dizziness


  • Overdose may lead to severe diarrhea and potential dehydration.
  • In case of overdose, contact poison control or seek emergency medical attention immediately.


  • Store at room temperature, away from moisture and heat.
  • Keep the medication in its original container, tightly closed, and out of reach of children.

Additional Information:

  • Not recommended for use in pregnant or breastfeeding women unless deemed necessary by a healthcare provider.
  • Patients should be advised to maintain adequate hydration while taking Trulance.