What is Savaysa (Lixiana)?

Savaysa, marketed as Lixiana in Canada, is a direct oral anticoagulant (DOAC) containing edoxaban. It is used for:

• Prevention of stroke and systemic embolism: In patients with non-valvular atrial fibrillation (NVAF).
• Treatment of venous thromboembolism (VTE): Including deep vein thrombosis (DVT) and pulmonary embolism (PE).

Lixiana works by selectively inhibiting Factor Xa, a key enzyme in the blood clotting process, preventing abnormal clot formation and reducing associated risks.

Benefits of Lixiana

• Convenient Dosing: Taken as a once-daily tablet.
• No Routine Monitoring: Unlike warfarin, it does not require regular INR testing.
• Lower Bleeding Risk: Associated with fewer bleeding complications compared to traditional anticoagulants.
• Cost Savings: Buying Lixiana from Canada offers significant financial benefits for U.S. patients.

Dosage and Administration

Recommended Dosages

• NVAF: 60 mg once daily.
• VTE Treatment: 60 mg once daily following 5-10 days of initial parenteral anticoagulation.

Reduced Dose

A reduced dose of 30 mg once daily is recommended for patients with:

• Moderate to severe renal impairment (CrCl 15-50 mL/min).
• Body weight ≤ 60 kg.
• Concurrent use of certain P-glycoprotein inhibitors.

If a dose is missed, take it as soon as possible on the same day. Do not double doses to make up for a missed one.

How Lixiana Compares to Other DOACs

Lixiana is often compared to other DOACs such as:

• Eliquis (apixaban): Known for its twice-daily dosing and excellent safety profile.
• Xarelto (rivaroxaban): Offers similar once-daily dosing for most indications.
• Pradaxa (dabigatran): Requires twice-daily dosing and has specific reversal agents.

Lixiana’s once-daily dosing and lower bleeding risk make it a convenient and effective choice for many patients.

Contraindications

Lixiana is contraindicated in the following cases:

• Active bleeding or conditions with a high risk of bleeding.
• Severe hepatic impairment.
• Concomitant use with other anticoagulants (except during switching).
• Pregnancy and breastfeeding.

Potential Side Effects

Common Side Effects

• Bleeding (e.g., bruising, nosebleeds).
• Nausea.
• Anemia.

Serious Side Effects

• Major bleeding (e.g., gastrointestinal or intracranial).
• Hypersensitivity reactions.

If severe or persistent symptoms occur, discontinue use and contact your healthcare provider immediately.

Storage and Handling

• Store at room temperature (15-30°C).
• Keep in original packaging to protect from moisture and light.
• Do not use expired tablets.

Why Buy Lixiana from Canada?

For Americans, buying Lixiana from Canada offers:

• Significant Savings: Regulated pricing in Canada ensures that medications like Lixiana are 30-50% cheaper than in the U.S.
• High Quality: Medications meet strict regulatory standards.
• Convenience: Canadian online pharmacies, such as Over the Border Meds, specialize in serving U.S. patients.

Coupons and Discounts

Many Canadian pharmacies offer additional savings through coupon codes or bulk purchase discounts. Look for promotional codes such as Hello10 for 10% off your first order of Lixiana.

Similar Medications

Other anticoagulants you might consider include:

• Eliquis (apixaban): Effective for stroke prevention and VTE treatment.
• Xarelto (rivaroxaban): Known for its once-daily dosing.
• Warfarin: A traditional anticoagulant requiring regular INR monitoring.

Discuss these options with your doctor to determine the most suitable treatment.

How to Buy Lixiana from Canada

1. Obtain a Prescription: Ensure you have a valid prescription from your U.S. healthcare provider.
2. Select a Pharmacy: Choose a reputable Canadian pharmacy, such as Over the Border Meds.
3. Submit Your Order: Upload your prescription and complete the order process online or by fax.
4. Receive Your Medication: Enjoy cost savings and peace of mind with your delivery.