+1 833 209-3704
GLP-1s and Blood Pressure: How These Medications Lower More Than Just A1C
GLP-1s and Blood Pressure: How These Medications Lower More Than Just A1C
- Todd P
If you’re living with Type 2 diabetes, you’ve likely heard of GLP-1 medications like Ozempic, Wegovy, Mounjaro, or Rybelsus. These drugs are known for their A1C-lowering effects and their ability to promote weight loss. But there’s another benefit that’s becoming increasingly important: lowering blood pressure.
Many Americans with diabetes also suffer from hypertension, a major risk factor for heart attack, stroke, and kidney disease. Fortunately, GLP-1 receptor agonists (GLP-1s) have been shown to improve blood pressure in addition to blood sugar—a double benefit that’s reshaping how we treat metabolic disease.
In this article, we’ll explore the connection between GLP-1s and blood pressure, share what the latest research says, and explain how Americans can save significantly by buying GLP-1 medications from Canada through trusted services like Over the Border Meds.
What Are GLP-1 Medications?
GLP-1 stands for glucagon-like peptide-1, a naturally occurring hormone that:
Stimulates insulin release after meals
Reduces glucagon (a hormone that raises blood sugar)
Slows digestion
Promotes satiety and weight loss
Medications like Ozempic (semaglutide), Mounjaro (tirzepatide), and Trulicity (dulaglutide) mimic this hormone to improve blood sugar control. They are approved to treat Type 2 diabetes and, in some cases, obesity.
🩺 How GLP-1s Help Lower Blood Pressure
Research suggests GLP-1s lower blood pressure through multiple mechanisms:
Weight loss: Even modest weight loss reduces pressure on blood vessels
Improved vascular function: GLP-1s may enhance the ability of blood vessels to dilate
Natriuresis: These drugs promote sodium excretion, which can lower fluid retention
Reduced sympathetic activity: GLP-1s may help calm the nervous system’s stress response
📉 How Much Can They Lower Blood Pressure?
Most clinical trials show a modest but meaningful reduction in systolic and diastolic blood pressure:
| GLP-1 Medication | Systolic BP Reduction | Diastolic BP Reduction |
|---|---|---|
| Ozempic | ~4–6 mmHg | ~1–2 mmHg |
| Trulicity | ~3–5 mmHg | ~1 mmHg |
| Mounjaro | ~5–7 mmHg | ~2–3 mmHg |
These reductions may seem small, but each 5 mmHg decrease in systolic blood pressure is associated with:
A 10% lower risk of major cardiovascular events
A 13% lower risk of stroke
A 7% lower risk of death from heart disease
Clinical Studies Supporting BP Benefits
Several trials have demonstrated the blood pressure-lowering effect of GLP-1s:
SUSTAIN-6 (Ozempic)
Semaglutide reduced both A1C and blood pressure in patients with high cardiovascular risk. BP reductions were observed even in those already taking antihypertensives.
SURPASS-2 (Mounjaro)
Tirzepatide outperformed semaglutide in reducing both blood glucose and systolic blood pressure, especially in patients with obesity and Type 2 diabetes.
AWARD Trials (Trulicity)
Dulaglutide consistently showed blood pressure improvements over placebo and insulin glargine.
Why Americans Are Ordering GLP-1s from Canada
While GLP-1s are effective, they are expensive in the U.S.—often $1,000 to $1,400 per month. Many insurance plans do not cover them unless a patient meets strict criteria, leaving people to pay out of pocket.
That’s where ordering from Canada becomes a game-changer.
Cost Comparison: U.S. vs. Canada (via Over the Border Meds)
| Medication | U.S. Price (avg) | Over the Border Meds |
|---|---|---|
| Ozempic 1 mg | $1,200+ | ~$419 USD |
| Wegovy 2.4 mg | $1,400+ | ~$599 USD |
| Mounjaro 10 mg Pen | $1,100+ | ~$699 USD |
| Rybelsus 14 mg (oral) | $900+ | ~$295 USD |
Over the Border Meds helps U.S. patients:
Legally import up to a 90-day supply
Use valid U.S. prescriptions
Order brand-name medications only
Get meds delivered directly to their home
Use coupon code Hello10 to receive 10% off your first order.
Can GLP-1s Replace Blood Pressure Medications?
Not necessarily. While GLP-1s lower blood pressure, they are not substitutes for antihypertensives like ACE inhibitors or calcium channel blockers. However, they may:
Enhance blood pressure control
Allow for dose reduction of other BP meds
Offer additional heart protection in patients with diabetes
Always talk to your doctor before making any changes to your medication regimen.
GLP-1s Offer Whole-Body Benefits
GLP-1 receptor agonists aren’t just for diabetes anymore. With proven benefits for:
Weight loss
Blood pressure
Cholesterol levels
Heart health
…it’s no surprise they’re being adopted for broader use in high-risk patients—even those without diabetes.
💬 FAQs: GLP-1s and Blood Pressure
1. Do I need high blood pressure to benefit from GLP-1s?
No. Even if your blood pressure is normal, GLP-1s may help you maintain healthy levels—especially if you’re overweight or have insulin resistance.
2. Will I need fewer BP meds if I start a GLP-1?
Possibly. Weight loss and improved vascular function may reduce your need for other medications, but this should always be done under medical supervision.
3. Are GLP-1s safe for people with heart disease?
Yes. In fact, many GLP-1s are approved specifically to reduce cardiovascular risk in patients with diabetes and heart disease.
4. Can I order GLP-1s from Canada if I live in the U.S.?
Yes. U.S. patients can legally import a 90-day supply for personal use through a Canadian prescription referral service like Over the Border Meds.
🩺 Final Thoughts
GLP-1 medications offer far more than just A1C control—they are powerful tools for improving blood pressure, reducing cardiovascular risk, and supporting long-term metabolic health.
But with rising U.S. costs, many Americans are priced out of treatment. That’s why services like Over the Border Meds are helping patients save on Ozempic, Wegovy, Mounjaro, and more—by legally sourcing medications from Canada.
📌 Learn more and place your first order at Over the Border Meds today.