Can You Take Eliquis with Aspirin?

Can You Take Eliquis with Aspirin?

If you’ve been prescribed Eliquis (apixaban) to help prevent blood clots or stroke, you may be wondering if it’s safe to take aspirin at the same time. Both medications thin the blood, so it’s important to understand when combining them is necessary—and when it can be dangerous.

In this post, we’ll explain the risks, when the combination might be appropriate, what to watch out for, and how Americans can save money by ordering Eliquis from Canada through a trusted prescription referral service.

What Is Eliquis?

Eliquis is a prescription blood thinner used to reduce the risk of stroke in people with atrial fibrillation (AFib), treat deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevent future blood clots after surgery.

It works by blocking Factor Xa, a protein involved in the formation of blood clots. As a result, Eliquis reduces the blood’s ability to clot—making it helpful, but also potentially dangerous if mixed with other blood thinners like aspirin.

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Can You Take Aspirin with Eliquis?

The short answer: sometimes—but only if your doctor recommends it.

Aspirin is an over-the-counter antiplatelet drug that can also prevent clots. When taken with Eliquis, the risk of bleeding increases, especially in the stomach, intestines, or brain.

However, in certain situations, your doctor may prescribe both:

  • After certain heart procedures like stent placement

  • If you have coronary artery disease (CAD) along with AFib

  • In select cases of peripheral artery disease (PAD)

But outside of these specific medical scenarios, it’s not typically recommended to take both unless your provider believes the benefit outweighs the bleeding risk.

Bottles of Apixaban

Signs to Watch For

If your doctor has prescribed both Eliquis and aspirin, or you’re taking them together, watch for signs of serious bleeding, such as:

  • Unusual bruising

  • Nosebleeds that don’t stop

  • Pink, red, or dark urine

  • Black or bloody stools

  • Vomiting blood or material that looks like coffee grounds

  • Dizziness or fainting

If you notice any of these symptoms, call your doctor or seek medical attention immediately.

You should also avoid combining Eliquis with other blood thinners, such as ibuprofen (Advil), naproxen (Aleve), or other NSAIDs, unless directed by your provider.

Why Do Doctors Sometimes Recommend Both?

While the combination of aspirin and Eliquis increases bleeding risk, there are times when dual therapy is beneficial. For example:

  • A patient with AFib who also recently had a heart attack may be placed on short-term dual therapy to prevent clot formation.

  • A patient with a coronary stent may need aspirin to prevent clots in the stent, while Eliquis helps prevent stroke from AFib.

In these cases, doctors closely monitor the dose and duration of both medications to reduce risks. Most often, dual therapy is temporary—aspirin may be discontinued after a few months.

Always let your provider know about all medications you are taking, including over-the-counter aspirin, vitamins, or supplements.

Buying Eliquis from Canada to Save Money

In the U.S., the cost of Eliquis can exceed $600 per month if you’re uninsured or not covered by Medicare. That’s why more and more Americans are turning to online Canadian prescription referral services like Over the Border Meds to save money.

Eliquis is available from Canada at a fraction of the U.S. price—and even more affordable is generic apixaban, which is available in Canada but not yet widely in the U.S.

Ordering is simple:

  • Upload your valid U.S. prescription

  • Choose your medication (brand or generic)

  • Receive it at your home, often in 5–10 business days

With rising drug prices in the U.S., many Americans are saving hundreds of dollars per month by choosing Canadian options through trusted services.

Final Thoughts

So, can you take Eliquis and aspirin together? Only if your doctor advises it. The combination can be risky but may be needed in some heart-related conditions. Never start aspirin on your own if you’re taking Eliquis—always check with your healthcare provider.

If you’re struggling with the high cost of Eliquis, consider exploring affordable options from Canada. Services like Over the Border Meds offer a safe, licensed way for Americans to access the same medications at a much lower price.