Compounded Semaglutide to End in the U.S. by May 22, 2025: Your Alternative Options

Compounded Semaglutide to End in the U.S. by May 22, 2025: Your Alternative Options

The FDA has officially announced that compounded semaglutide will no longer be permitted after May 22, 2025. This decision comes as the supply of brand-name GLP-1 medications like Ozempic and Wegovy stabilizes, reducing the justification for allowing compounded alternatives.

For many U.S. patients who turned to compounded semaglutide due to shortages or high costs, this change means they will need to seek alternatives. One option is to purchase Ozempic or Wegovy from Canada, where prices are significantly lower than in the U.S.

Why Was Compounded Semaglutide Allowed?

Compounded semaglutide became available in the U.S. as a response to drug shortages of Ozempic and Wegovy. When a commercially manufactured medication is in short supply, the FDA temporarily allows compounding pharmacies to create alternatives using the active ingredient.

However, compounding pharmacies are not regulated the same way as pharmaceutical manufacturers. Many compounded versions of semaglutide were made using semaglutide sodium or other unapproved forms, which may not be bioequivalent to the FDA-approved medication. This led to concerns about safety, effectiveness, and quality control.

Why Is Compounded Semaglutide Being Phased Out?

The FDA has determined that the national supply of Ozempic and Wegovy has stabilized, meaning compounding is no longer necessary. Under U.S. regulations, once a drug is readily available, compounded versions must be discontinued.

Starting May 22, 2025, U.S. pharmacies and clinics will no longer be allowed to compound and sell semaglutide. Patients currently using compounded versions will need to transition to Ozempic, Wegovy, or Rybelsus.

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How Can U.S. Patients Save on Ozempic or Wegovy?

Many patients turned to compounded semaglutide because it was cheaper than brand-name Ozempic or Wegovy. With compounding no longer an option, buying from Canada may be the most affordable solution.

Why Consider Buying from Canada?

  • Lower cost: Ozempic and Wegovy prices in Canada may be 30–50% cheaper than in the U.S.
  • Same brand-name medication: Unlike compounded versions, purchasing from a licensed Canadian pharmacy ensures you receive the authentic drug from Novo Nordisk.
  • No need for a Canadian prescription: A valid U.S. prescription is all that is required.

How Much Does Ozempic or Wegovy Cost in Canada?

  • Ozempic: $419.00 per pen
  • Wegovy: $599.00 per pen (equivalent to four doses in the U.S.)

For U.S. patients facing high out-of-pocket costs or insurance restrictions, ordering from a Canadian pharmacy is a cost-effective alternative.

ozempic and wegovy as alternatives to compounded semaglutide

What Should Patients Do Next?

If you are currently using compounded semaglutide, now is the time to discuss alternatives with your doctor. Transitioning to Ozempic, Wegovy, or Rybelsus before the May 2025 deadline can help ensure continuity of treatment without any disruptions. Your healthcare provider can guide you on the best option based on your medical history, weight loss goals, and insurance coverage.

It’s also important to consider how you will access the medication affordably. Many patients turned to compounded semaglutide because it was a cheaper alternative to the brand-name versions, so transitioning may lead to higher out-of-pocket costs. Exploring options like buying from a Canadian pharmacy can help offset these costs, as prices in Canada are significantly lower than in the U.S.

For those without insurance coverage or those facing high co-pays, now is the time to compare pricing, check eligibility for manufacturer savings programs, and explore international pharmacy options to ensure ongoing access to treatment.

Conclusion

With the FDA set to end compounded semaglutide on May 22, 2025, patients who relied on these versions will need to switch to brand-name medications like Ozempic, Wegovy, or Rybelsus. While this change ensures patients receive an FDA-approved product, it may also lead to higher costs for those who relied on compounding for affordability.

For U.S. patients concerned about price increases, purchasing from Canada offers a safe and affordable alternative. Canadian pharmacies provide access to authentic Ozempic and Wegovy at significantly lower prices, allowing patients to continue their treatment without financial strain.

Now is the time to plan ahead, consult with a healthcare provider, and explore cost-saving options to maintain access to semaglutide therapy without disruption.

References:

FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize