How to Safely Take Apixaban with Herbal Supplements and Over-the-Counter Medications

How to Safely Take Apixaban with Herbal Supplements and Over-the-Counter Medications

Apixaban, sold under the brand name Eliquis, is a commonly prescribed blood thinner used to prevent blood clots, strokes, and other cardiovascular issues. While effective, apixaban carries a risk of bleeding, especially when combined with certain supplements or over-the-counter (OTC) medications.

If you’re on apixaban, you might wonder whether it’s safe to take fish oil, turmeric, or even pain relievers like ibuprofen. This guide will walk you through the most common interactions and how to stay safe.

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Supplements That May Increase Bleeding Risk

Many herbal supplements have blood-thinning effects of their own. When combined with apixaban, the risk of excessive bleeding may increase. The following supplements are best discussed with your doctor before use:

  • Turmeric: Often used for inflammation, turmeric contains curcumin, which can thin the blood and increase bleeding risk.
  • Fish oil (omega-3 fatty acids): In high doses, fish oil can reduce clotting and may intensify the effect of apixaban.
  • Garlic supplements: Raw garlic and garlic pills are known to affect platelet function, which may raise bleeding risk.
  • Ginkgo biloba: This supplement can increase bleeding risk and is not generally recommended with apixaban.
  • Ginseng: May interfere with clotting pathways and affect how blood thinners work.
  • Vitamin E (in high doses): High levels can act as a blood thinner.

Always check the label of multivitamins and herbal blends, as they may include ingredients that interact with your blood thinner.

Over-the-Counter Medications to Avoid or Use Cautiously

Certain non-prescription medications can also affect bleeding risk. Here’s what to be cautious with:

  • NSAIDs (ibuprofen, naproxen): These medications are commonly used for pain but can significantly increase the risk of gastrointestinal bleeding when taken with apixaban. Avoid unless specifically approved by your doctor.
  • Aspirin: Even low-dose aspirin can add to the blood-thinning effect of apixaban. It should only be taken if your doctor has instructed you to do so.
  • Cold and flu products: Some contain NSAIDs, so check the ingredients carefully.
  • Antacids and acid reducers: Some can affect drug absorption. Talk to your provider about preferred options if you’re treating heartburn.

If you need pain relief while on Eliquis, acetaminophen (Tylenol) is usually considered the safer option, but even this should be taken within recommended doses and with your doctor’s knowledge.

Can You Take Vitamins with Eliquis?

Most standard daily multivitamins are safe, but it’s important to avoid high doses of vitamin E, and always be cautious of any blend marketed for heart health or joint pain, as these may contain turmeric or fish oil.

Vitamin K does not interfere with Eliquis (unlike warfarin), so you don’t need to adjust your diet or avoid leafy greens.

When to Call Your Doctor

You should speak with your healthcare provider before:

  • Starting any new supplement, even if it’s natural or labeled “safe”
  • Taking any over-the-counter pain relievers or cold medications
  • Adding herbal teas, detox kits, or weight loss supplements to your routine
  • Planning dental work or minor procedures

Signs of abnormal bleeding, such as unusual bruising, dark stools, or bleeding gums, should always be reported promptly.

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Accessing Eliquis at a Lower Cost

If you’re taking apixaban long-term, the cost can add up, especially if you’re paying out of pocket. Many Americans are now saving money by ordering their apixaban or generic versions from Canada. Through trusted prescription referral services like Over the Border Meds, you can get the same Health Canada-approved medication at a lower price.

Generic apixaban is available in Canada at a much lower cost compared to U.S. pharmacy prices for brand-name Eliquis.

Final Thoughts

Apixaban is an effective medication for preventing serious cardiovascular events, but it’s essential to understand how other supplements and medications may impact its safety. Always check with your healthcare provider before starting anything new, and read ingredient labels carefully.

Taking a cautious, informed approach, and exploring affordable prescription options from Canada, can help you manage your condition more safely and cost-effectively