Does Mounjaro Help with Heart Health? What the Research Says

May 1, 2025
Jason K

Mounjaro (tirzepatide) has gained widespread attention for its powerful effects on blood sugar control and weight loss, but many patients are now asking an important follow-up question: Does Mounjaro help with heart health too?

The short answer: early studies suggest yes, and ongoing clinical trials are working to confirm it. In this article, we’ll explore what’s currently known about Mounjaro and its potential to improve cardiovascular outcomes—especially for people with Type 2 diabetes, obesity, or metabolic syndrome.

We’ll also cover how Americans can access Mounjaro more affordably from Canada through prescription referral services like Over the Border Meds, especially if insurance doesn’t cover it.

What Is Mounjaro?

Mounjaro is the brand name for tirzepatide, a once-weekly injectable medication approved for Type 2 diabetes and now also prescribed for chronic weight management under the name Zepbound.

Unlike older GLP-1 drugs like Ozempic or Wegovy, Mounjaro has a dual mechanism:

GLP-1 receptor agonist: Improves insulin secretion and reduces appetite
GIP receptor agonist: Enhances insulin sensitivity and may further reduce fat accumulation

This combination has shown greater A1C reductions and weight loss than semaglutide in clinical trials.

Mounjaro pen starting at $599

Can Mounjaro Benefit Heart Health?

Although Mounjaro was first approved for blood sugar control, early data and metabolic improvements suggest it may also reduce cardiovascular risk in high-risk populations.

Cardiovascular health is a major concern for people with:

Type 2 diabetes
Obesity
High blood pressure
High cholesterol

These risk factors often overlap—and medications that improve weight, blood sugar, blood pressure, and cholesterol can contribute to reduced risk of heart attack, stroke, and death.

What Does the Research Say So Far?

While we don’t yet have final cardiovascular outcome trial (CVOT) data for Mounjaro, we do have several key findings:

✅ 1. Weight Loss Improves Heart Health

In the SURPASS clinical trial program, patients lost up to 22.5% of their body weight with Mounjaro. Weight loss alone is associated with:

Reduced blood pressure
Lower LDL cholesterol
Improved glucose and insulin sensitivity
Decreased inflammation

Each of these changes independently reduces cardiovascular risk.

✅ 2. Improved A1C and Blood Pressure

Mounjaro has consistently demonstrated greater A1C reductions than semaglutide and insulin glargine. In some trials, it also reduced systolic blood pressure by 5–8 mmHg, which significantly lowers the risk of stroke and heart disease.

✅ 3. Lower Inflammatory Markers

Inflammation plays a big role in cardiovascular disease. Preliminary data suggest Mounjaro may reduce C-reactive protein (CRP), an inflammatory marker linked to atherosclerosis and heart attack risk.

What’s Coming Next: The SURPASS-CVOT Trial

The SURPASS-CVOT (Cardiovascular Outcomes Trial) is currently underway and will provide definitive evidence on whether Mounjaro reduces:

Cardiovascular death
Heart attack
Stroke

This trial compares Mounjaro to dulaglutide (Trulicity), which has already been shown to improve cardiovascular outcomes. If Mounjaro performs better, it could become a first-line treatment for high-risk patients with diabetes and heart disease.

Results are expected by late 2024 or 2025.

Why Cardiologists Are Paying Attention

Given its:

Significant weight loss
Strong glucose control
Blood pressure and lipid benefits
Potential inflammation reduction

…it’s no surprise that cardiologists and endocrinologists are watching Mounjaro closely. In fact, many are already prescribing it to diabetic patients with known cardiovascular risk while waiting for official CVOT results.

How to Save on Mounjaro by Ordering from Canada

One barrier for U.S. patients? Cost. Mounjaro can cost over $1,100/month without insurance—and many plans don’t cover it for weight loss.

At Over the Border Meds, you can access brand-name Mounjaro from Canada at much lower prices:

Mounjaro Strength	Price from Canada
2.5 mg – 15 mg pens	~$599-799 USD
Vials (for microdosing)	~$158-188 per vial

Patients also receive:

Help with click counting (for dose adjustments)
Support with determining pen needles and titration
Personalized pharmacy assistance if switching from Saxenda, Ozempic, or another GLP-1

✅ Use coupon code MounjaroIsBack for 10% off your first order.

Final Thoughts

Mounjaro is already reshaping how we manage Type 2 diabetes and obesity—but the emerging evidence also suggests it could be a powerful tool in protecting heart health.

While we await the final SURPASS-CVOT results, the metabolic improvements seen in Mounjaro users point toward a likely cardiovascular benefit.

If you’re considering Mounjaro and want to save significantly, especially if you’re paying out-of-pocket, explore safe, affordable access from Canada through Over the Border Meds. Our pharmacy team is here to guide you every step of the way.