How to Use Ozempic: Step-by-Step Instructions for Safe and Effective Use

How to Use Ozempic: Step-by-Step Instructions for Safe and Effective Use

Ozempic (semaglutide) is a once-weekly injectable medication used to treat Type 2 diabetes and is also commonly prescribed off-label for weight management. If you’re new to Ozempic or just need a refresher, it’s important to understand the correct way to store, use, and dispose of your Ozempic pen to ensure safety and effectiveness.

This guide will walk you through the entire process—from priming your pen to injecting your dose, including how to get help from the pharmacy team at Over the Border Meds if you order Ozempic from Canada.

You can also reference the official Novo Nordisk guide to using Ozempic for visual instructions and support materials.

Step 1: Storing Your Ozempic Pen

Before your first use:

  • Store Ozempic in the refrigerator (36°F to 46°F or 2°C to 8°C)

  • Do not freeze—if it freezes, you must throw it away

  • Keep it in the original packaging to protect it from light

After first use:

  • You can store the pen at room temperature (below 86°F or 30°C) for up to 56 days

  • Always put the cap back on to protect it from light

  • Do not leave it in a car, direct sunlight, or near heat

2 boxes of Ozempic

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Step 2: Preparing for Your Injection

 

Here’s what you’ll need:

  • Your Ozempic pen

  • A new disposable needle (BD pen needles work well)

  • Alcohol swab

  • Sharps container for used needles

Wash your hands thoroughly before getting started.

Boxes of Wegovy pens

Step 3: Attaching a New Needle (Change It Every Time!)

 

Always use a new needle for each injection to:

  • Prevent infection

  • Ensure the correct dose is delivered

  • Keep the needle sharp and comfortable

Steps:

1. Remove the pen cap

2. Peel the protective seal from a new needle

3. Screw the needle straight onto the pen

4. Remove both the outer and inner needle caps

Never reuse needles. Reusing can lead to blocked or bent needles, and it increases your risk of infection.

Step 4: Priming the Ozempic Pen (First Use)

 

Before your first dose, you should prime the pen. This removes air and ensures the pen is working.

Steps:

1. Turn the dose selector to the flow check symbol (-)

2. Hold the pen with the needle pointing up

3. Tap the pen gently to move air bubbles to the top

4. Press and hold the dose button until you see a drop of liquid at the needle tip

No drop = pen may not be working or the needle may be blocked. Try again with a new needle.

Step 5: Injecting Your Ozempic Dose

 

Once primed, you’re ready to inject.

Steps:

1. Turn the dose selector to your prescribed dose (e.g., 0.25 mg, 0.5 mg, or 1 mg)

2. Clean your injection site (abdomen or thigh) with an alcohol swab

3. Insert the needle into your skin and press the dose button until the dose counter shows 0

4. Keep holding the button for 6 seconds to make sure the full dose is delivered

5. Remove the pen and dispose of the needle in a sharps container

Alternate your injection sites to prevent irritation or scarring.

What to Do If the Ozempic Pen Isn’t Working

 

Common issues:

  • No liquid during priming? Attach a new needle and try again

  • Can’t turn dose selector? The pen may be empty or faulty

  • Pen doesn’t deliver full dose? Replace the pen and notify your doctor or pharmacist

  • Pen looks cloudy or discolored? Do not use it

If you order Ozempic from Over the Border Meds, our pharmacy team is available to answer any pen handling or dosing questions. Just email us or call our support line for guidance.

How Over the Border Meds Can Help

 

Ordering Ozempic from Canada through Over the Border Meds can save you hundreds of dollars. Plus, we provide:

  • 💊 Authentic Ozempic from licensed Canadian pharmacies

  • 📦 Direct U.S. shipping

  • 📞 Pharmacist support for new users

  • 💵 Coupon code Hello10 for 10% off your first order

Whether you’re unsure about priming the pen, adjusting your dose, or switching from another GLP-1 medication, our team is here to help.

Quick Recap: Ozempic Use Checklist

 

  • ✅ Store properly (refrigerate before use; room temp after)

  • ✅ Use a new needle every time

  • ✅ Prime the pen when using a new needle

  • ✅ Inject in the thigh or abdomen—alternate sites

  • ✅ Hold the button for 6 seconds after the dose counter reaches 0

  • ✅ Dispose of the needle safely

Final Thoughts

 

Using Ozempic correctly helps ensure you’re getting the full benefit of your medication. Whether you’re starting for blood sugar management or weight loss, proper technique is key to seeing results and avoiding side effects.

If you’re ready to start or continue Ozempic treatment, consider ordering from Over the Border Meds—a trusted Canadian prescription referral service offering lower prices and real pharmacy support for U.S. patients.

📌 Visit Over the Border Meds to learn more or place your order.