+1 833 209-3704
Switching from Saxenda to Mounjaro: Transitioning for Better Weight Loss
If you’ve been using Saxenda (liraglutide) for weight management and are considering switching to Mounjaro (tirzepatide), you’re not alone. Both medications are GLP-1 receptor agonists that promote weight loss, but Mounjaro adds an extra mechanism by targeting GIP receptors, potentially making it more powerful. This guide will cover the differences between Saxenda and Mounjaro, explain how to make the switch, and provide answers to common questions.
Why More People Are Switching from Saxenda to Mounjaro
With the rise of medications targeting GLP-1 receptors for weight loss, more patients are switching from Saxenda to Mounjaro. Mounjaro’s dual-action mechanism, which targets both GLP-1 and GIP receptors, has shown more significant weight loss in clinical trials, drawing the attention of those seeking better results. Additionally, its weekly injection schedule offers greater convenience compared to Saxenda’s daily injections. As more people look for effective, long-term weight loss solutions, Mounjaro is becoming a popular choice for those who want enhanced results with fewer injections.
Comparing Saxenda and Mounjaro
| Feature | Saxenda (Liraglutide) | Mounjaro (Tirzepatide) |
|---|---|---|
| Mechanism | GLP-1 receptor agonist | GLP-1 and GIP receptor agonist |
| Dosing Frequency | Daily injection | Weekly injection |
| Average Weight Loss | 5-10% of body weight | 15-20% of body weight |
| FDA Approval | Weight loss and type 2 diabetes | Primarily for type 2 diabetes (approved for weight loss as Zepbound) |
| Side Effects | Nausea, vomiting, diarrhea | Nausea, vomiting, diarrhea, abdominal discomfort |
| Cost (Approx.) – USA | $1,349 per month | $1,023 per month |
| Cost (Approx.) – Canada | $620 per month | $620 per month |
| Injection Sites | Thigh, upper arm, abdomen | Thigh, upper arm, abdomen |
Key Differences
- Mechanism of action: Mounjaro targets both GLP-1 and GIP receptors, which may offer more effective weight loss than Saxenda’s single-target GLP-1 action.
- Dosing frequency: Mounjaro is administered weekly, which many patients find more convenient than Saxenda’s daily injections.
- Weight loss potential: Mounjaro has shown higher average weight loss in clinical trials than Saxenda, making it an appealing option for those looking to achieve significant weight loss results.
- Cost: Mounjaro is often less expensive than Saxenda, especially when purchasing from Canada, where the cost is significantly lower.
Understanding Saxenda
Saxenda is a GLP-1 receptor agonist used for weight management and type 2 diabetes treatment. It works by mimicking a hormone called GLP-1, which helps regulate appetite and insulin. Saxenda is injected daily and helps individuals feel full, leading to reduced calorie intake.
- Active ingredient: Liraglutide
- Dosage: Daily injection
- Mechanism of action: GLP-1 receptor agonist
- Common side effects: Nausea, vomiting, diarrhea, and decreased appetite
- USA Price: Around $1,349 per month
- Canada Price: Around $510 per month
Understanding Mounjaro
Mounjaro is a newer medication used primarily for type 2 diabetes management, but it’s gaining popularity for its potential in weight loss. Unlike Saxenda, Mounjaro targets both GLP-1 and GIP receptors, making it a dual-action medication. It is injected weekly, offering a more convenient option for many patients.
- Active ingredient: Tirzepatide
- Dosage: Weekly injection
- Mechanism of action: GLP-1 and GIP receptor agonist
- Common side effects: Nausea, vomiting, diarrhea, decreased appetite, and stomach pain
- USA Price: Around $1,023 per month
- Canada Price: Around $620 per month
How to Actually Switch from Saxenda to Mounjaro
Switching from Saxenda to Mounjaro can be an effective strategy if you’re not seeing the weight loss results you’d hoped for or are looking for a more convenient dosing schedule. Follow these steps for a smooth transition:
1. Consult Your Healthcare Provider
The first step in switching from Saxenda to Mounjaro is to talk with your doctor. Your healthcare provider will assess your medical history, current health status, and weight loss goals to determine if switching is right for you. They may also discuss the potential side effects of both medications and how to manage them.
2. Stop Taking Saxenda
Once your doctor approves the switch, they will likely recommend stopping Saxenda for a short period. This allows your body to reset before introducing a new medication. The waiting period may vary based on your personal medical history, but typically, this could be around 1-2 days.
3. Start Mounjaro at a Low Dose
Your doctor will likely start you on a lower dose of Mounjaro (typically 2.5 mg per week) to help your body adjust. Over time, they will gradually increase the dosage, as tolerated, until you reach the dose that aligns with your weight loss goals.
4. Monitor for Side Effects
Both Saxenda and Mounjaro can cause gastrointestinal side effects such as nausea, vomiting, and diarrhea. Be prepared for these symptoms during the transition period. Your healthcare provider may suggest remedies or adjustments to help manage these side effects as you adjust to Mounjaro.
5. Maintain a Healthy Lifestyle
Both medications suppress appetite, so it’s essential to continue a healthy eating plan and exercise regimen while transitioning from Saxenda to Mounjaro. This will help you optimize weight loss results and maintain your progress.
References
Scientific American: Comparison between Mounjaro and other GLP-1 medications for weight loss.
Reference: “Mounjaro and Ozempic Weight-Loss Comparison”National Institutes of Health (NIH): Study comparing GLP-1 agonists like Saxenda and Mounjaro.
Reference: NIH GLP-1 Study