What is Xeljanz XR?

Xeljanz XR (tofacitinib extended-release) is a prescription medication used to treat autoimmune conditions such as:

• Rheumatoid Arthritis (RA): In adults who have not responded adequately to methotrexate.
• Psoriatic Arthritis (PsA): In adults with active PsA.
• Ulcerative Colitis (UC): For the treatment of moderate to severe active ulcerative colitis.

Xeljanz XR belongs to a class of medications known as Janus kinase (JAK) inhibitors, which work by reducing immune system activity to decrease inflammation and manage symptoms of autoimmune diseases. Its extended-release formulation allows for once-daily dosing, providing convenience for patients.

How Does Xeljanz XR Work?

Xeljanz XR works by inhibiting Janus kinases, enzymes involved in the inflammatory processes of the immune system. By blocking these enzymes, Xeljanz XR helps reduce the overactive immune response associated with autoimmune diseases, leading to decreased inflammation, pain, and joint damage.

For conditions like rheumatoid arthritis, patients may begin to notice symptom relief within 2 to 6 weeks of starting treatment. However, maximum benefits, such as significant reductions in joint pain and swelling, may take up to 3 months to achieve. For ulcerative colitis, improvements in bowel symptoms can often be seen within 8 weeks, with sustained results over time.

Benefits of Xeljanz XR

• Convenient Dosing: Extended-release tablets provide once-daily dosing.
• Effective Symptom Relief: Reduces inflammation, pain, and swelling in affected joints.
• Improved Quality of Life: Helps patients regain mobility and manage symptoms more effectively.
• Alternative to Biologics: Offers an oral treatment option for those who prefer not to use injections.
• Flexible Use: Approved for multiple autoimmune conditions, making it a versatile treatment option.

Dosage and Administration

The recommended dose of Xeljanz XR for rheumatoid arthritis and psoriatic arthritis is 11 mg taken orally once daily. For ulcerative colitis, the dose may differ based on your doctor’s instructions.

Missed Dose:

• If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose.
• Do not double up on doses to make up for the missed one.

It’s important to take Xeljanz XR consistently at the same time each day to maintain optimal drug levels in your body.

Side Effects of Xeljanz XR

Common Side Effects:

• Headache
• Diarrhea
• Nausea
• Upper respiratory tract infections
• Fatigue

Serious Side Effects:

• Infections: Increased risk of serious infections, including tuberculosis and fungal infections.
• Blood Clots: Potential risk of deep vein thrombosis (DVT) and pulmonary embolism (PE).
• Liver Problems: Elevated liver enzymes may require monitoring.
• Increased Cancer Risk: Rare cases of lymphoma and other cancers have been reported.

If you experience severe side effects, contact your healthcare provider immediately. Regular blood tests may be recommended to monitor for potential complications during treatment.

Alternatives to Xeljanz XR

Several alternative medications are available for treating autoimmune conditions like rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. These include:

• Humira (adalimumab): A biologic therapy used to treat various autoimmune diseases. Administered via injection.
• Enbrel (etanercept): Another injectable biologic for rheumatoid arthritis and psoriatic arthritis.
• Remicade (infliximab): An infusion-based biologic used for ulcerative colitis and other conditions.
• Otezla (apremilast): An oral medication specifically for psoriatic arthritis and plaque psoriasis.

Your healthcare provider can help determine which treatment is best suited to your specific condition and lifestyle preferences.

Use in Special Populations

Pregnancy:

There is limited information on the use of Xeljanz XR during pregnancy. It should only be used if the potential benefits justify the risks. Consult your doctor if you are pregnant or planning to become pregnant.

Breastfeeding:

It is not known if Xeljanz XR passes into breast milk. Breastfeeding while taking this medication is not recommended without consulting your healthcare provider.

Why Buy Xeljanz XR from Canada?

Cost Savings:

Medications like Xeljanz XR are often significantly cheaper in Canada due to regulated drug pricing. Americans can save up to 50% or more by purchasing from Canadian pharmacies.

Quality Assurance:

Canadian pharmacies adhere to stringent quality control standards, ensuring medications are authentic and safe.

Ease of Access:

With a valid prescription, you can order Xeljanz XR online from reputable Canadian pharmacies and have it shipped directly to your home.

How to Save Even More

• Coupons: Look for promotional discounts for first-time orders.
• Bulk Purchases: Ordering a 90-day supply often reduces overall costs.
• Referral Programs: Many pharmacies offer credits or discounts for referring new customers.
• Insurance Coordination: Some Canadian pharmacies assist with reimbursement claims to further reduce costs.