Xadago (Safinamide) Tablets

What is Xadago?

Xadago, known as Onstryv in Canada, is a medication prescribed to help manage symptoms of Parkinson’s disease in patients experiencing “off” episodes. These episodes occur when the effects of other Parkinson’s medications, like levodopa, start to wear off, resulting in stiffness, slowness, and other movement difficulties. Xadago, an MAO-B inhibitor, works by prolonging the effects of dopamine in the brain, helping to control movement symptoms and improve the overall quality of life for Parkinson’s patients.

How Xadago Works

Xadago selectively inhibits an enzyme known as monoamine oxidase B (MAO-B). By doing so, it helps to maintain dopamine levels in the brain, which are crucial for movement and coordination. This action supports levodopa treatment, reducing “off” episodes and improving motor function in individuals with Parkinson’s disease. Xadago must be taken alongside levodopa/carbidopa for effectiveness.

Xadago Dosage and Administration

Xadago is typically prescribed in doses of 50 mg once daily. After two weeks, your healthcare provider may increase the dose to 100 mg daily based on your response and tolerance. It’s essential to take Xadago at the same time each day, with or without food. Note that exceeding the recommended dose may increase the risk of side effects, including hypertension and serotonin syndrome. Always follow your healthcare provider’s instructions for optimal results.

Possible Side Effects of Xadago

Common side effects of Xadago include:

• Dyskinesia (involuntary muscle movements)
• Nausea
• Insomnia
• Falls

Serious but less common side effects include:

• Serotonin syndrome (high fever, agitation, increased reflexes)
• Hallucinations and psychotic behavior
• Impulse control issues (uncontrollable urges)
• Hypertension

If you experience any serious side effects, contact your healthcare provider immediately.

Drug Interactions

Xadago may interact with certain medications, including:

• Other MAO inhibitors
• Opioid drugs (e.g., tramadol, methadone)
• Antidepressants (SSRIs, SNRIs)
• Dextromethorphan

To avoid interactions, inform your healthcare provider of all medications and supplements you’re taking.

Precautions When Using Xadago

Before starting Xadago, inform your healthcare provider if you have:

• High or low blood pressure
• Heart problems
• History of mental health conditions, such as bipolar disorder or psychosis
• Liver impairment

These conditions may require dosage adjustments or additional monitoring while using Xadago.

Buying Xadago from Canada

For U.S. patients, buying Xadago from Canada, where it is sold as Onstryv, can provide significant savings. Here are some steps for a safe purchase:

• Check Pharmacy Licensing: Ensure the Canadian pharmacy is licensed and reputable.
• Consult Your Doctor: Discuss with your doctor whether purchasing from Canada is suitable for your condition.
• Understand U.S. Import Guidelines: The FDA typically allows a 90-day supply of medication for personal use to be imported.
• Valid Prescription: A U.S. prescription is required to order Xadago from Canada.

Following these steps will help ensure you obtain genuine medication safely and at a lower cost.

Storage Instructions for Xadago

Store Xadago tablets at room temperature, between 15°C and 30°C (59°F and 86°F), away from moisture and heat. Ensure that the medication is kept out of reach of children and pets.

Frequently Asked Questions (FAQs)

What is the difference between Xadago and Onstryv?

In the U.S., safinamide is branded as Xadago, while in Canada, it is sold as Onstryv. Both products are identical in composition and effectiveness, just marketed under different names.

Can Xadago be taken as a standalone treatment for Parkinson’s disease?

No, Xadago is not approved as a standalone treatment for Parkinson’s. It is only effective when used as an adjunct therapy with levodopa/carbidopa.

Is there a generic version of Xadago?

Currently, there is no generic version of Xadago available. However, purchasing Xadago from Canada may offer significant cost savings.

How can I save on Xadago costs?

Buying from licensed Canadian pharmacies often offers U.S. patients significant savings compared to domestic prices.

For more detailed information, refer to the official product monograph here.