What is Trulance (Plecanatide)?

Trulance, the brand name for plecanatide, is a prescription medication used to treat adults with irritable bowel syndrome with constipation (IBS-C). It works by increasing fluid secretion in the intestines, promoting softer stools and more frequent bowel movements, and reducing abdominal pain caused by IBS-C.

Trulance offers a once-daily oral tablet formulation, making it convenient for managing IBS-C symptoms effectively.

How Trulance Works

Trulance is a guanylate cyclase-C (GC-C) agonist. It binds to receptors in the intestinal lining, leading to increased secretion of chloride and bicarbonate ions. This promotes fluid movement into the intestines, facilitating easier stool passage and improved intestinal transit. Additionally, it helps reduce visceral pain associated with IBS-C.

Benefits of Trulance

Trulance provides several benefits for adults with IBS-C:

• Effective Symptom Relief: Improves stool frequency, reduces abdominal pain, and alleviates straining.
• Simple Dosing: A single 3 mg tablet taken once daily, with or without food.
• Minimal Systemic Absorption: Acts locally in the intestines, with negligible absorption into the bloodstream, reducing the risk of systemic side effects.
• Cost Savings: Buying Trulance from Canada offers significant financial relief for U.S. patients due to lower drug prices.

Dosage and Administration

The recommended dose of Trulance is 3 mg taken orally once daily. It can be taken with or without food. Patients with swallowing difficulties can crush the tablet and mix it with applesauce or water.

Missed Dose

If you miss a dose, skip it and take your next dose at the regular time. Do not double up on doses.

Use During Pregnancy

Pregnant patients should consult their healthcare provider before starting Trulance. While there are limited studies on its use in pregnancy, animal studies suggest no harm to the fetus at therapeutic doses. However, the benefits and risks should be assessed by a medical professional.

Contraindications

Trulance is contraindicated in:

• Patients with known or suspected mechanical gastrointestinal obstruction.
• Children under the age of 6 due to the risk of severe dehydration.
• Patients with a history of hypersensitivity to plecanatide or any other ingredients in Trulance.

Always inform your healthcare provider about any existing medical conditions or medications to avoid potential interactions or adverse effects.

Side Effects of Trulance

While Trulance is generally well-tolerated, some patients may experience:

• Diarrhea (the most common side effect)
• Nausea
• Abdominal pain or cramping
• Headache

If severe diarrhea or dehydration occurs, discontinue use and contact your healthcare provider immediately.

Why Buy Trulance from Canada?

For Americans, buying Trulance from Canada offers a cost-effective solution. Canadian pharmacies provide high-quality medications at a fraction of U.S. prices due to stricter price regulations.

Cost Savings

Purchasing Trulance from Canada can save you up to 50% compared to U.S. pharmacy prices, making it an ideal option for patients seeking affordable IBS-C treatment.

Trusted Quality

Canadian pharmacies adhere to rigorous regulatory standards, ensuring you receive genuine, high-quality medications. When you buy from a reputable Canadian pharmacy, you gain access to the same trusted brands at lower costs.

Coupons and Savings

To save even more, look for available coupons when purchasing Trulance from Canada. Trusted pharmacies like Over the Border Meds often provide discounts for first-time customers. Use coupon codes to receive additional savings on your medication.

How to Order Trulance from Canada

Ordering Trulance from Canada is simple:

1. Obtain a Prescription: Ensure your U.S. doctor provides a valid prescription for Trulance.
2. Choose a Reliable Pharmacy: Select a trusted Canadian pharmacy, such as Over the Border Meds, specializing in serving U.S. patients.
3. Place Your Order: Submit your prescription online, provide shipping details, and complete payment.
4. Receive Your Medication: Your Trulance will be delivered to your doorstep promptly.