Simbrinza (Brinzolamide/Brimonidine) From Canada

What is Simbrinza?

Simbrinza is a prescription ophthalmic suspension that contains two active ingredients: brinzolamide and brimonidine tartrate. It is used to reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, especially when other treatments are insufficient. Simbrinza works by decreasing the production of fluid in the eye, reducing pressure and preventing further damage to the optic nerve.

How Simbrinza Works

Simbrinza contains two agents with different mechanisms of action. Brinzolamide is a carbonic anhydrase inhibitor that decreases the production of aqueous humor (eye fluid), while brimonidine is an alpha-2 adrenergic agonist that also decreases fluid production and increases fluid outflow. Together, these agents lower eye pressure, helping to prevent vision loss due to glaucoma.

Simbrinza Dosage and Administration

The recommended dose of Simbrinza is one drop in the affected eye(s) twice daily. Shake the bottle well before use. After instilling the drops, patients are advised to close their eyes or use nasolacrimal occlusion to reduce systemic absorption of the medication. If using other eye medications, allow at least 5 minutes between applying Simbrinza and any other ophthalmic product.

Do not allow the dropper to touch your eye or any other surface to prevent contamination, and discard the bottle 125 days after opening.

Possible Side Effects of Simbrinza

Common side effects include:

• Blurred vision
• Dry mouth
• Fatigue
• Eye irritation

Serious but rare side effects include allergic reactions, such as swelling or difficulty breathing. If you experience these, stop using the product and seek medical attention immediately.

Drug Interactions

Simbrinza may interact with the following medications:

• Monoamine oxidase inhibitors (MAOIs)
• Tricyclic antidepressants
• Other alpha-adrenergic agents
• Oral carbonic anhydrase inhibitors

Patients should inform their healthcare provider of all medications they are taking before starting Simbrinza to avoid interactions.

Precautions When Using Simbrinza

Before using Simbrinza, inform your doctor if you:

• Have a history of kidney or liver problems
• Are pregnant or breastfeeding
• Are allergic to sulfonamides

Simbrinza is not recommended for use in children or patients with severe renal impairment. Additionally, it should not be used in patients with narrow-angle glaucoma or those receiving MAOI therapy.

Buying Simbrinza from Canada

U.S. patients can save money by purchasing Simbrinza from licensed Canadian pharmacies. Ensure that the pharmacy is reputable and that you have a valid U.S. prescription before buying. Consult with your healthcare provider if you are considering purchasing Simbrinza from outside the U.S.

Storage Instructions for Simbrinza

Store Simbrinza at room temperature between 2°C and 25°C (36°F to 77°F). Keep the bottle tightly closed and protect it from moisture and light. Discard the bottle 125 days after opening. Keep out of reach of children and pets.

Frequently Asked Questions (FAQs)

What is Simbrinza used for?

Simbrinza is used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Can I buy Simbrinza from Canada?

Yes, U.S. patients can buy Simbrinza from licensed Canadian pharmacies. A valid U.S. prescription is required for the purchase.

How should I use Simbrinza?

Use one drop of Simbrinza in the affected eye(s) twice daily. Shake the bottle well before use, and avoid contaminating the dropper tip by keeping it away from surfaces and your eye.

Simbrinza provides a dual-action approach to lowering intraocular pressure in patients with open-angle glaucoma or ocular hypertension. For U.S. patients seeking a cost-effective option, purchasing Simbrinza from Canada can offer significant savings. Always consult your healthcare provider before making any changes to your treatment plan or buying medications from international sources.

For more detailed information, you can refer to the official product monograph here.

To use Simbrinza eye drops, shake the bottle well before each use. Tilt your head back, pull down your lower eyelid, and squeeze one drop into the eye as directed. Close your eye and press gently on the inner corner for a minute to prevent the medication from draining. Always follow your doctor's instructions and avoid touching the dropper tip to any surface.