What is Protopic Ointment?

Protopic Ointment, also known by its generic name tacrolimus ointment, is a topical medication used to treat moderate to severe atopic dermatitis (eczema) in patients who are not adequately responsive to or cannot tolerate conventional therapies. It is available in two strengths: 0.03% for children aged 2-15 and 0.03% or 0.1% for adults and adolescents aged 16 and older.

Protopic is a calcineurin inhibitor that works by suppressing the immune response in the skin, reducing inflammation, itching, and redness associated with eczema. It is a non-steroidal option, making it a preferred choice for long-term management in patients who want to avoid side effects like skin thinning associated with steroids.

Uses of Protopic Ointment

• Treatment of Active Eczema: Effective for short-term management of eczema flares.
• Maintenance Therapy: Helps prevent flares and prolong periods of remission in patients with frequent exacerbations.
• Facial and Sensitive Areas: Suitable for areas where steroid use is not recommended, such as the face and neck.

Why Buy Protopic Ointment from Canada?

For U.S. patients, purchasing Protopic Ointment from Canada offers significant financial benefits. Canadian pharmacies provide the same high-quality medication at regulated prices, making it an affordable solution for managing eczema.

Cost Savings

By buying Protopic Ointment from Canada, you can save up to 50% compared to U.S. pharmacy prices. This is especially beneficial for patients requiring long-term therapy.

Trusted Quality

Canadian pharmacies adhere to stringent regulatory standards, ensuring the safety and efficacy of medications. Purchasing from reputable providers guarantees the same high-quality Protopic as in the U.S.

Coupons and Discounts

Look for first-time customer coupons or bulk-purchase discounts offered by Canadian pharmacies to further reduce costs.

How Protopic Ointment Works

Protopic inhibits T-cell activation by binding to an intracellular protein called FKBP-12. This process suppresses the production of inflammatory cytokines, which play a key role in eczema symptoms. Unlike corticosteroids, Protopic does not cause skin thinning or other steroid-related side effects, making it ideal for sensitive areas.

Dosage and Administration

Protopic Ointment should be applied as a thin layer to affected areas of the skin. It is typically used:

• Twice Daily for Active Flares: Continue until the eczema clears or is significantly reduced, usually within 6 weeks.
• Twice Weekly for Maintenance: Helps prevent flares in patients prone to frequent exacerbations.

Avoid occlusive dressings and wash hands thoroughly after application unless treating the hands. Follow your healthcare provider's instructions for best results.

Potential Side Effects

Common Side Effects:

• Burning or stinging sensation
• Itching
• Redness at the application site

Rare but Serious Side Effects:

• Increased risk of skin infections
• Skin malignancies (rare)
• Lymphoma (rare)

If you experience severe or persistent symptoms, discontinue use and consult your healthcare provider.

Special Considerations

Use in Pregnancy and Breastfeeding

There is limited data on the use of Protopic during pregnancy. It should be used only if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should avoid using Protopic, as tacrolimus is excreted in breast milk.

Contraindications

• Hypersensitivity to tacrolimus or any other ingredients in the ointment.
• Use in children under 2 years of age.

Sun Exposure

Patients should minimize or avoid natural or artificial sunlight exposure while using Protopic, as it may increase sensitivity to UV radiation.

Storage and Handling

• Store at room temperature (15°C to 30°C).
• Keep the tube tightly closed and out of reach of children.
• Do not freeze or expose to excessive heat.

Alternatives to Protopic Ointment

While Protopic is highly effective, other options include:

• Eucrisa (crisaborole): A non-steroidal option for mild to moderate eczema.
• Topical Corticosteroids: Effective but may cause skin thinning with prolonged use.
• Dupixent (dupilumab): An injectable biologic for severe eczema.

Discuss these options with your doctor to determine the best treatment plan.