What is Otezla?

Otezla (apremilast) is an oral medication used to treat:

• Moderate to severe plaque psoriasis: For adults who are candidates for phototherapy or systemic therapy.
• Psoriatic arthritis: Can be used alone or with methotrexate for adults unresponsive to prior therapies.
• Oral ulcers associated with Behçet's disease: For adults requiring systemic treatment.

Otezla works by inhibiting phosphodiesterase 4 (PDE4), which reduces inflammation and helps manage symptoms of these conditions.

Why Buy Otezla from Canada?

For Americans, buying Otezla from Canada can lead to significant savings. Canadian pharmacies offer high-quality medications at regulated prices, making Otezla more affordable compared to U.S. costs.

Cost Savings

Purchasing Otezla from Canada can save you up to 50% or more, providing a cost-effective solution for managing psoriasis and psoriatic arthritis.

Trusted Sources

Canadian pharmacies adhere to stringent safety and quality standards, ensuring that the Otezla you purchase meets the highest regulatory requirements.

Dosage and Administration

Starting Dose (Titration):

• Day 1: 10 mg in the morning.
• Day 2: 10 mg in the morning and evening.
• Day 3: 10 mg in the morning and 20 mg in the evening.
• Day 4: 20 mg in the morning and evening.
• Day 5: 20 mg in the morning and 30 mg in the evening.
• Day 6 and beyond: 30 mg twice daily.

Maintenance Dose:

The recommended dose is 30 mg twice daily, taken with or without food.

Potential Side Effects

Common Side Effects:

• Nausea
• Diarrhea
• Headache
• Fatigue
• Weight loss

Serious Side Effects:

• Depression or suicidal thoughts
• Severe diarrhea, nausea, or vomiting
• Rare cardiovascular events such as tachyarrhythmia

If you experience severe or persistent symptoms, contact your healthcare provider immediately.

Use in Pregnancy and Breastfeeding

Pregnancy: Otezla is contraindicated during pregnancy due to potential risks to the fetus. Women of childbearing age should use effective contraception during treatment and discontinue use if planning to conceive.

Breastfeeding: It is unknown whether Otezla is excreted in human milk. Breastfeeding mothers should avoid using this medication.

Contraindications

• Known hypersensitivity to apremilast or its ingredients.
• Pregnant women or those attempting to conceive.
• Women who are breastfeeding.
• Severe renal impairment (requires dosage adjustment).

Drug Interactions

Avoid combining Otezla with strong CYP3A4 inducers, such as rifampin, as they can reduce its effectiveness. Consult your doctor about potential interactions with other medications you may be taking.

Storage and Stability

• Temperature: Store at 15°C to 30°C (59°F to 86°F).
• Packaging: Keep in the original container to protect from light and moisture.

Clinical Insights

Mechanism of Action

Otezla inhibits PDE4, increasing intracellular cAMP levels and reducing pro-inflammatory cytokines like TNF-α and interleukin-23. This mechanism alleviates inflammation and improves symptoms of psoriasis and psoriatic arthritis.

Efficacy in Clinical Trials

Otezla achieved significant improvements in Psoriasis Area and Severity Index (PASI-75) scores in up to 33% of patients within 16 weeks. It also demonstrated reductions in joint swelling and tenderness in psoriatic arthritis.

How to Order Otezla from Canada

1. Consult Your Doctor: Obtain a valid U.S. prescription for Otezla.
2. Choose a Canadian Pharmacy: Select a reputable pharmacy that caters to U.S. patients, such as Over the Border Meds.
3. Submit Your Prescription: Upload your prescription and place your order online.
4. Receive Your Medication: Your Otezla will be delivered securely to your home.