What is Orgovyx?

Orgovyx (relugolix) is an oral gonadotropin-releasing hormone (GnRH) receptor antagonist used to treat advanced prostate cancer. It works by reducing the production of testosterone, a hormone that can fuel the growth of prostate cancer cells. Unlike traditional injectable hormone therapies, Orgovyx is taken as a once-daily tablet, offering a convenient alternative to patients.

Why Buy Orgovyx from Canada?

In the United States, Orgovyx can be expensive, costing patients hundreds to thousands of dollars per month. However, buying from a Canadian online pharmacy can offer significant savings. As of 2025, the cost of Orgovyx in Canada for U.S. patients is approximately $399 for a 30-day supply, making it a more affordable option.

How Does Orgovyx Work?

Orgovyx functions by blocking GnRH receptors in the pituitary gland, reducing luteinizing hormone (LH) and follicle-stimulating hormone (FSH) production. This leads to a rapid decrease in testosterone levels, helping slow the progression of prostate cancer.

Clinical trials have shown that Orgovyx effectively maintains testosterone suppression with fewer cardiovascular risks compared to traditional injectable androgen deprivation therapies (ADT) such as leuprolide.

Orgovyx Dosage and Administration

The recommended dosage of Orgovyx for prostate cancer is:

• Loading dose: 360 mg (three 120 mg tablets) on the first day.
• Maintenance dose: 120 mg (one tablet) taken orally once daily.

It should be taken at the same time each day, with or without food. Patients who miss a dose should take it as soon as they remember, unless it is more than 12 hours late, in which case the missed dose should be skipped.

Common Side Effects of Orgovyx

While Orgovyx is generally well-tolerated, some patients may experience side effects, including:

• Hot flashes
• Fatigue
• Diarrhea or constipation
• Muscle and joint pain
• Increased blood sugar and cholesterol levels
• Low red blood cell count (anemia)

In rare cases, Orgovyx may cause serious heart problems, such as QT prolongation, which can lead to irregular heartbeats. Patients with pre-existing heart conditions should discuss this risk with their healthcare provider before starting treatment.

Drug Interactions

Orgovyx may interact with several medications, including:

• Oral P-gp inhibitors (e.g., erythromycin) – may increase Orgovyx levels.
• Strong CYP3A inducers (e.g., rifampin) – may decrease Orgovyx effectiveness.
• QT-prolonging medications – may increase heart rhythm risks.
• Diuretics and laxatives – may cause electrolyte imbalances, increasing the risk of QT prolongation.

Patients should inform their doctor about all medications they are taking before starting Orgovyx.

Orgovyx in Pregnancy and Breastfeeding

Orgovyx is not approved for use in women and should not be used during pregnancy or breastfeeding. It may harm an unborn baby if taken by a pregnant woman. Male patients should use effective contraception during treatment and for at least two weeks after stopping Orgovyx.

Contraindications

Orgovyx should not be used in patients who:

• Are allergic to relugolix or any of its components.
• Are taking medications that significantly prolong the QT interval.
• Have severe heart rhythm disorders without proper monitoring.

Storage and Handling

• Store Orgovyx at room temperature between 15°C and 30°C.
• Keep the bottle tightly closed and away from moisture.
• Do not dispose of unused tablets in wastewater or household trash; return them to a pharmacy.

Coupon for Orgovyx

Patients looking to save on Orgovyx may be eligible for discounts or coupons when purchasing from Canada. Check with Over The Border Meds for available savings options.

How to Order Orgovyx from Canada

Buying Orgovyx from Canada is simple and can save patients hundreds of dollars each month. To order:

1. Obtain a valid U.S. prescription from your doctor.
2. Choose a reputable Canadian online pharmacy, such as Over The Border Meds.
3. Submit your prescription online or via fax at 1-833-209-3704.
4. Complete the order and wait for secure delivery to your address.