Combigan (Brimonidine Tartrate and Timolol Maleate) From Canada

Combigan is an ophthalmic solution containing two active ingredients: brimonidine tartrate (0.2%) and timolol maleate (0.5%). It is used to lower intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. By reducing the pressure inside the eye, Combigan helps to prevent damage to the optic nerve and preserve vision.

Combigan is typically prescribed for patients who do not achieve adequate IOP reduction with monotherapy, providing an effective combination of a selective alpha-2 adrenergic receptor agonist and a beta-blocker to lower eye pressure more effectively than either medication alone.

How Combigan Works

Combigan works through two mechanisms. Brimonidine tartrate lowers IOP by reducing the production of aqueous humor (the fluid inside the eye) and increasing its outflow. Timolol maleate, a beta-blocker, also reduces aqueous humor production. Together, these two medications help to maintain a healthy level of pressure inside the eye and slow the progression of glaucoma.

Combigan Dosage and Administration

Combigan is administered as eye drops, with the typical dose being one drop in the affected eye(s) twice daily, approximately 12 hours apart. The solution contains 0.2% brimonidine tartrate and 0.5% timolol maleate, and it should be used exactly as prescribed by your healthcare provider. It’s important to avoid contamination by not allowing the tip of the dropper to touch the eye or any surface.

If you miss a dose, apply it as soon as possible. If it’s close to your next dose, skip the missed dose and return to your regular schedule. Do not double the dose.

Possible Side Effects of Combigan

Common side effects of Combigan may include:

• Eye redness
• Itching or irritation
• Dry mouth
• Blurred vision
• Fatigue

Serious side effects may include:

• Severe eye irritation or pain
• Decreased heart rate
• Breathing difficulties, especially in patients with asthma or chronic obstructive pulmonary disease (COPD)
• Allergic reactions, such as swelling or hives

Contact your healthcare provider immediately if you experience any severe or unusual side effects.

Drug Interactions

Combigan may interact with other medications, such as:

• Beta-blockers (systemic or topical)
• Calcium channel blockers
• Antidepressants (MAO inhibitors and tricyclics)
• Clonidine or other alpha-agonist medications
• Antiarrhythmic medications

Be sure to inform your doctor about all medications, supplements, and herbal products you are taking to avoid potential interactions.

Precautions When Using Combigan

Before using Combigan, inform your healthcare provider if you have:

• A history of heart problems (e.g., heart block, congestive heart failure)
• Respiratory issues, such as asthma or COPD
• Kidney or liver impairment
• Low blood pressure

Pregnant and breastfeeding women should consult their doctor before using Combigan, as its safety has not been fully established in these populations.

Buying Combigan from Canada

For U.S. patients, purchasing Combigan from Canada can offer substantial savings, as Canadian prices for prescription medications are often lower. To ensure safety, follow these guidelines:

• Buy from a licensed online Canadian pharmacy.
• Ensure you have a valid prescription from a U.S. healthcare provider.
• Consult your doctor before purchasing medications from another country to ensure it is appropriate for you.

Storage Instructions for Combigan

Store Combigan eye drops at room temperature (15°C to 25°C / 59°F to 77°F), away from moisture, heat, and direct light. Keep the bottle tightly closed when not in use and out of reach of children and pets. Discard the product after its expiration date.

Frequently Asked Questions (FAQs)

What is Combigan used for?

Combigan is used to reduce intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Can I buy Combigan from Canada?

Yes, U.S. patients can purchase Combigan from licensed Canadian pharmacies, often at a lower price. A valid prescription is required.

How should I take Combigan?

Apply one drop in the affected eye(s) twice daily, approximately 12 hours apart. Follow your doctor’s instructions closely.

Combigan provides a dual-action approach to lowering intraocular pressure in patients with glaucoma or ocular hypertension, helping to prevent further vision loss. For those looking to save on prescription costs, buying Combigan from a Canadian pharmacy can be a cost-effective option. Always consult with your healthcare provider before starting or changing any medication regimen, and ensure you are following all safety guidelines.

For more detailed information, you can refer to the official product monograph here.