What is Orilissa?

Orilissa (elagolix) is an oral gonadotropin-releasing hormone (GnRH) receptor antagonist used to treat moderate to severe pain associated with endometriosis. By regulating estrogen levels, it helps reduce endometriosis-related pain while maintaining hormonal balance.

Endometriosis is a condition where tissue similar to the lining of the uterus grows outside the uterus, causing pain, inflammation, and fertility issues. Orilissa works by reducing the hormones that trigger this abnormal tissue growth, helping to relieve symptoms effectively.

Why Buy Orilissa from Canada?

In the U.S., Orilissa can be expensive, with high out-of-pocket costs for patients without insurance. However, buying from a licensed Canadian pharmacy offers substantial savings. Patients can purchase Orilissa at a lower price while receiving the same high-quality medication.

Additionally, Canadian pharmacies are known for their strict regulatory standards, ensuring that medications are safe and effective. By purchasing from Canada, American patients can access Orilissa without financial strain while benefiting from world-class pharmaceutical quality.

How Does Orilissa Work?

Orilissa blocks GnRH receptors in the pituitary gland, leading to a reduction in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels. This results in decreased estrogen levels, which helps alleviate pain caused by endometriosis.

Unlike other hormonal treatments that completely suppress estrogen, Orilissa allows for partial estrogen suppression. This means it helps relieve symptoms while minimizing the risk of severe side effects related to estrogen depletion, such as osteoporosis.

Orilissa Dosage and Administration

• 150 mg once daily: Recommended for up to 24 months.
• 200 mg twice daily: Recommended for up to 6 months due to potential bone mineral density loss.

Take Orilissa at the same time each day, with or without food. If a dose is missed, take it as soon as possible within the same day.

For best results, patients should follow their prescribed regimen closely and consult their doctor if symptoms persist or worsen.

Common Side Effects of Orilissa

• Hot flashes
• Headache
• Fatigue
• Insomnia
• Joint pain
• Changes in mood (depression, anxiety, irritability)

In some cases, Orilissa may also cause a decrease in bone mineral density, which could lead to long-term bone health issues. Patients should discuss their bone health with their doctor before starting Orilissa.

Drug Interactions

• Strong OATP1B1 inhibitors (e.g., cyclosporine, gemfibrozil) – may increase Orilissa levels.
• Strong CYP3A inducers (e.g., rifampin) – may reduce Orilissa effectiveness.
• Hormonal contraceptives – may lower Orilissa’s effectiveness.

Women using birth control should discuss non-hormonal alternatives with their healthcare provider, as Orilissa may interact with estrogen-based contraceptives.

Use in Pregnancy and Breastfeeding

Orilissa is not recommended during pregnancy as it may cause early pregnancy loss. Patients should use non-hormonal contraception while taking Orilissa.

Orilissa is also not recommended for breastfeeding mothers, as it may pass into breast milk and affect the baby’s hormonal development.

Orilissa Coupons and Discounts

Patients looking for additional savings can use an Orilissa coupon code when ordering from a Canadian pharmacy. First-time buyers may be eligible for discounts, making their medication more affordable.

For example, Over The Border Meds offers discounts such as Hello10 for 10% off first-time purchases, helping patients lower their costs even further.

How to Order Orilissa from Canada

1. Obtain a Prescription: Ensure you have a valid prescription from your U.S. healthcare provider.
2. Select a Trusted Pharmacy: Choose a reputable Canadian pharmacy, such as Over The Border Meds.
3. Place Your Order: Submit your prescription and complete the order process.
4. Receive Your Medication: Your medication will be shipped directly to your address.

By following these steps, patients can receive safe, effective, and affordable Orilissa from Canada.