Nurtec ODT (Rimegepant): Uses, Dosing, Side Effects & How It Works

Nurtec ODT (rimegepant) 75 mg is an orally disintegrating tablet for the acute treatment of migraine with or without aura in adults. It belongs to the class of CGRP receptor antagonists, which block calcitonin gene-related peptide signaling thought to drive migraine symptoms.

What Nurtec ODT Is Used For

• Acute treatment of migraine attacks (with or without aura) in adults.

It is not approved for prevention, and pediatric use has not been authorized in Canada.

 

Dosing (General Information)

• Recommended dose: 75 mg as needed for a migraine attack; maximum 75 mg in 24 hours.
• Monthly limit: Safety of taking more than 15 doses in 30 days has not been established.
• How to take: With dry hands, peel back the blister foil. Place the ODT on or under the tongue; it dissolves and can be swallowed without water. May be taken with or without food.
• Renal/hepatic: Avoid use in severe hepatic impairment and in end-stage renal disease/dialysis; ask your clinician if unsure.

 

Common Side Effects & Safety

• Nausea was the most common adverse reaction in studies.
• Hypersensitivity (including dyspnea and rash) occurred rarely and can be delayed; stop and seek care if suspected.

Serious adverse events were uncommon in trials; long-term safety in open-label use has been described.

 

Drug Interactions

• Avoid strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, ritonavir). Moderate inhibitors (e.g., fluconazole, erythromycin, diltiazem) can increase exposure—dose spacing may be needed.
• Avoid strong/moderate CYP3A4 inducers (e.g., rifampin, St. John’s wort, bosentan, efavirenz, modafinil) due to reduced efficacy.
• Strong P-gp inhibitors (e.g., cyclosporine, quinidine, verapamil): avoid a second dose within 48 hours of coadministration.
• Grapefruit juice may increase exposure.

Always discuss prescription/OTC drugs, supplements, and herbals with your prescriber.

 

Special Populations

• Pregnancy: No adequate human data; use only if benefits outweigh risks.
• Breastfeeding: A lactation study suggests low transfer into milk; discuss with your clinician.
• Geriatrics: Limited experience; no clinically meaningful PK differences vs younger adults observed.

Not authorized for pediatric use (<18 years).

 

How Nurtec ODT Works

Rimegepant blocks the CGRP receptor, a key pathway implicated in migraine. By inhibiting CGRP signaling, it helps relieve headache pain and associated symptoms.

 

Nurtec ODT vs. Triptans (and vs. Ubrelvy)

Nurtec ODT (rimegepant) is a CGRP receptor antagonist, while triptans (e.g., sumatriptan) are 5-HT_1B/1D agonists that can cause blood-vessel constriction. Here are practical differences to discuss with your prescriber:

• Vascular effects: Triptans may be unsuitable for some patients with certain cardiovascular conditions; Nurtec does not cause vasoconstriction.
• Onset & convenience: Nurtec is a single 75 mg ODT dose per attack; no water needed and can be taken with or without food.
• Repeat dosing limits: Do not exceed 75 mg in 24 hours with Nurtec; safety of >15 doses/month hasn’t been established. Triptan dosing/limits vary by product.
• Ubrelvy (ubrogepant) vs. Nurtec: Both are oral CGRP antagonists for acute migraine; dosing, interactions, and prescriber preference may differ. Choice often depends on clinical fit, prior response, and affordability.

Which is “best”? It depends on your health history, medication interactions, and how you respond to therapy. Your prescriber can help tailor the option that fits your needs.

 

Storage, Handling & Everyday Tips

• Storage: Keep blisters in the original package at room temperature; protect from moisture. Open with dry hands only when ready to dose.
• How to take: Peel back the foil (don’t push the tablet through). Place on or under the tongue; it dissolves without water.
• Hydration & triggers: Stay well hydrated and track common migraine triggers (sleep changes, stress, certain foods, alcohol). A simple headache diary can guide adjustments.
• Travel: Keep a dose in your carry-on. Because it’s an ODT, you can take it mid-flight without water.
• Other medications: Review all prescriptions/OTCs/herbals with your clinician—especially drugs affecting CYP3A4 or P-gp—and avoid grapefruit products unless your prescriber says otherwise.
• When to reassess: If attacks remain frequent, last longer, or you’re using acute meds too often, ask your prescriber about preventive strategies or adjusting your plan.

 

Lower Your Cost (For U.S. Patients)

• Price: $248.95 for 8 tablets (75 mg ODT).
• Shipping to U.S.: typically 5–10 business days after processing.

If Nurtec is expensive locally, Americans often look to Canadian prescription referral services to reduce out-of-pocket costs using a valid U.S. prescription for a personal-use supply.

 

How to Buy from Canada (Step-by-Step)

1. Get a valid U.S. prescription for Nurtec ODT (rimegepant) 75 mg.
2. Send your prescription: Your clinic can fax to 1-833-209-3704, or you can upload your prescription.
3. Place your order: Choose pack size and complete checkout.
4. Delivery: U.S. shipping typically 5–10 business days after processing (personal-use supply, usually up to 90 days).

 

When to Seek Medical Help

• Signs of severe allergic reaction (e.g., trouble breathing, swelling of face/lips/tongue, widespread rash)
• Any severe, persistent, or unusual symptoms after dosing

 

Ready to Order?

Buy Nurtec ODT (rimegepant) from Canada

Legal and Safety Information

This content is educational and not medical advice. Medications sourced via Canadian prescription referral services are for personal use by U.S. patients with a valid prescription. Always follow your prescriber’s instructions.

Use dry hands to open the blister pack, peel back the foil, and gently remove the tablet without pushing it through the foil. Place the tablet on or under your tongue, where it will dissolve in your saliva and can be swallowed without water.