Descovy (Emtricitabine/Tenofovir Alafenamide) Tablets

What is Descovy?

Descovy is a combination antiretroviral medication used in the treatment of human immunodeficiency virus (HIV-1) infection. It is also approved for pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 in at-risk individuals. Descovy contains two active ingredients: emtricitabine and tenofovir alafenamide. These components work by inhibiting the replication of the virus, helping to manage HIV infection and prevent the virus from spreading in at-risk individuals.

How Descovy Works

Descovy's active ingredients, emtricitabine and tenofovir alafenamide, block the action of reverse transcriptase, an enzyme that HIV uses to replicate its genetic material. By interfering with the virus's ability to replicate, Descovy helps reduce the amount of virus in the body, allowing the immune system to function more effectively. This makes Descovy an important part of combination antiretroviral therapy (ART) and an effective preventive measure for individuals at risk of contracting HIV.

Descovy Dosage and Administration

Descovy is available in two strengths: 200 mg/10 mg and 200 mg/25 mg. The appropriate dose depends on the patient's treatment plan and whether it is used for HIV treatment or PrEP. The usual dose for treating HIV-1 infection in combination with other antiretrovirals is one tablet (200 mg/25 mg) taken orally once daily. For PrEP, the dose is also 200 mg/25 mg once daily.

Patients should take Descovy with or without food and at the same time each day to maintain consistent drug levels in the body. For individuals on hemodialysis, the dose should be taken after the completion of dialysis. Always follow your healthcare provider's instructions regarding dosage and usage.

Possible Side Effects of Descovy

Common side effects of Descovy include:

• Nausea
• Diarrhea
• Fatigue
• Headache
• Abdominal pain

Serious but less common side effects may include:

• Lactic acidosis
• Severe liver problems
• Bone mineral density loss
• Kidney problems

If you experience any severe side effects, such as difficulty breathing, unusual fatigue, or persistent pain, contact your healthcare provider immediately. Regular monitoring of kidney function and bone health may be necessary during treatment with Descovy.

Drug Interactions

Descovy may interact with other medications, including antiretrovirals, anticonvulsants, and medications that affect kidney function. Caution should be taken when using Descovy with drugs that induce or inhibit certain enzymes like P-glycoprotein, as these may alter the concentration of Descovy in the bloodstream. Patients should inform their healthcare providers of all medications they are currently taking, including over-the-counter drugs and supplements.

Precautions When Using Descovy

Before starting Descovy, inform your healthcare provider if you have any history of kidney disease, bone problems, or liver disease, including hepatitis B virus (HBV) infection. Discontinuing Descovy in patients with HBV can lead to severe exacerbation of the infection. Regular blood tests to monitor kidney and liver function may be recommended during treatment.

Descovy is not recommended for use in individuals at risk of HIV infection from receptive vaginal sex, as its efficacy in this population has not been established. It is also not recommended for individuals with severe renal impairment (creatinine clearance below 30 mL/min) who are not on chronic hemodialysis.

Buying Descovy from Canada

U.S. patients can save significantly by purchasing Descovy from licensed Canadian pharmacies. Prices for prescription medications in Canada are typically lower due to different regulations. To purchase Descovy from Canada, you will need a valid U.S. prescription. Always ensure that you are buying from a reputable pharmacy to avoid counterfeit products.

Storage Instructions for Descovy

Store Descovy at room temperature (15°C to 30°C) in its original packaging, away from moisture and heat. Keep it out of reach of children and pets. Discard any unused or expired medication safely, and do not flush it down the toilet or throw it into the trash.

Frequently Asked Questions (FAQs)

What is Descovy used for?

Descovy is used for the treatment of HIV-1 infection and as pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV in at-risk adults and adolescents.

Can I buy Descovy from Canada?

Yes, Descovy is available from licensed Canadian pharmacies with a valid U.S. prescription. Many U.S. patients choose to buy from Canada due to the cost savings.

How should I take Descovy?

Descovy should be taken once daily, with or without food. Follow your healthcare provider’s instructions for dosage and make sure to take it at the same time each day for the best results.

For more detailed information, you can refer to the official product monograph here.

Descovy is typically taken once daily, with or without food, as directed by your healthcare provider. Swallow the tablet whole, and be sure to take it consistently at the same time each day to maintain its effectiveness. Always follow your doctor's instructions for proper dosing and do not miss doses.