Nurtec vs. Ubrelvy: Which Works Faster for Migraines?

Migraines are more than just headaches, they’re a disabling neurological condition that can cause severe pain, nausea, light sensitivity, and difficulty functioning. For many years, triptans like sumatriptan were the go-to treatment, but not all patients could tolerate them, especially those with cardiovascular risk factors.

In recent years, a new class of medications called CGRP receptor antagonists (gepants) has changed the landscape of migraine treatment. Two of the most commonly prescribed are Nurtec ODT (rimegepant) and Ubrelvy (ubrogepant). Both are FDA- and Health Canada–approved for acute migraine relief, but patients often ask: Which one works faster?

How Nurtec and Ubrelvy Work

Both Nurtec and Ubrelvy block the calcitonin gene-related peptide (CGRP) receptor, a key pathway involved in migraine attacks. By blocking CGRP, they reduce inflammation and pain signals in the brain.

Nurtec ODT (rimegepant): Dissolves on the tongue and can also be taken preventively every other day for some patients.
Ubrelvy (ubrogepant): A swallowable tablet available in 50 mg and 100 mg doses, taken as needed when a migraine starts.

Onset of Action: Which Works Faster?

Ubrelvy

Clinical studies show that some patients begin to feel relief from Ubrelvy as early as 1 hour after taking a dose.
By 2 hours, a significant number of patients report being pain-free or having relief from the most bothersome symptom (like light or sound sensitivity).
Its quick absorption may make it preferable for patients who want fast-acting relief.

Nurtec

Nurtec ODT begins working within 1 to 2 hours, with many patients reporting relief by the 2-hour mark.
It has the added benefit of providing sustained relief for up to 48 hours in some patients, which may reduce the likelihood of needing a second dose.
Because it dissolves under the tongue, it may be easier for patients experiencing nausea or vomiting during migraines.

Head-to-Head Speed Comparison

Ubrelvy tends to work slightly faster for some patients, with a greater number experiencing relief within 1 hour.
Nurtec is close behind and offers the advantage of longer-lasting relief, potentially reducing recurrence.

Nurtec for $248.95

Effectiveness Beyond Speed

While speed matters, effectiveness is also about how long relief lasts and whether the medication prevents recurrence.

Nurtec: Offers the dual option of acute treatment and prevention. Some patients take it every other day to reduce migraine frequency.
Ubrelvy: Approved only for acute use, but patients can repeat a dose after 2 hours if symptoms persist (up to 200 mg in 24 hours).

Side Effects and Safety

Both medications are generally well tolerated, with fewer cardiovascular concerns than triptans.

Nurtec ODT: Common side effects include nausea (in less than 3% of patients) and, rarely, hypersensitivity reactions.
Ubrelvy: Side effects include nausea, sleepiness, and dry mouth.

Neither drug is associated with medication-overuse headache, a common problem with older migraine therapies.

Cost and Access

In the U.S., both Nurtec and Ubrelvy are expensive without insurance, often over $600 for 8 to 10 tablets. Patients without strong coverage often explore ways to reduce costs, such as manufacturer coupons, patient assistance programs, or Canadian prescription referral services, which may offer the same medication at lower prices.

Choosing Between Nurtec and Ubrelvy

The right choice depends on patient priorities:

If speed is most important: Ubrelvy may offer a slight edge with earlier onset for some patients.
If long-lasting relief and prevention matter: Nurtec may be preferred since it can be used both acutely and preventively.
If nausea is a concern: Nurtec’s orally disintegrating tablet may be easier to take than a swallowed pill.
If dosing flexibility is needed: Ubrelvy allows a repeat dose within 24 hours, while Nurtec is limited to one dose per day.

FAQs

Which is faster: Nurtec or Ubrelvy?
Ubrelvy may work slightly faster, with relief sometimes beginning within 1 hour, while Nurtec generally works within 1–2 hours.

Can Nurtec be used daily?
Yes, Nurtec can be prescribed every other day for prevention, unlike Ubrelvy, which is only approved for acute treatment.

Do Nurtec and Ubrelvy have fewer side effects than triptans?
Yes. Unlike triptans, they are not linked to cardiovascular risks, making them safer for patients with heart disease or stroke history.

Can I switch between Nurtec and Ubrelvy?
Some patients may try both to see which provides the best relief, but this should be done under medical supervision.

Which is cheaper?
Pricing is similar in the U.S. Both can be costly without insurance, but options like prescription referral services in Canada may offer lower prices.

Conclusion

Both Nurtec and Ubrelvy have transformed migraine treatment by offering effective, non-triptan options. While Ubrelvy may provide relief a little faster, Nurtec offers longer-lasting benefits and preventive use. The best choice depends on your symptoms, lifestyle, and how quickly you need relief.

If you struggle with frequent or severe migraines, talk to your healthcare provider about whether Nurtec, Ubrelvy, or a combination of therapies is right for you.

Disclaimer: This article is for informational purposes only and not medical advice. Consult a licensed healthcare provider before starting or changing medications. Use reputable, licensed pharmacies to ensure safety.