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Breztri vs Trelegy: Which COPD Inhaler Is Right for You?
Breztri vs Trelegy: Which COPD Inhaler Is Right for You?
- Todd P
If you have COPD (chronic obstructive pulmonary disease), your doctor may have recommended a triple therapy inhaler—and two of the most commonly prescribed options are Breztri Aerosphere and Trelegy Ellipta. Both are designed to help reduce flare-ups, improve breathing, and support long-term lung function.
But which one is better for your condition? And how can U.S. patients save money on these costly medications?
In this article, we’ll break down the key differences between Breztri and Trelegy—including their ingredients, devices, dosing, side effects, and cost—while also explaining how you can order your COPD medication from Canada through a prescription referral service like Over the Border Meds and save significantly.
What Are Breztri and Trelegy?
Both Breztri and Trelegy are once-daily triple-combination inhalers used to treat moderate to severe COPD. They contain three classes of medications:
ICS (inhaled corticosteroid) to reduce inflammation
LAMA (long-acting muscarinic antagonist) to relax airway muscles
LABA (long-acting beta agonist) to improve airflow
These medications are not intended for asthma, and are usually prescribed after dual therapy options (like Spiriva or Symbicort) are no longer sufficient.
Breztri vs Trelegy: Ingredients Breakdown
| Medication | ICS | LAMA | LABA |
|---|---|---|---|
| Breztri | Budesonide | Glycopyrronium | Formoterol fumarate |
| Trelegy | Fluticasone | Umeclidinium | Vilanterol |
While both drugs offer triple therapy, the active ingredients differ, which may impact how your body responds. For instance, some patients may tolerate budesonide better than fluticasone, while others find one LABA more effective or experience fewer side effects.
Device and Inhaler Type
| Medication | Device | Type | Usage |
|---|---|---|---|
Breztri
| Aerosphere
| Pressurized MDI (pMDI)
| 2 inhalations once daily
|
| Trelegy | Ellipta | Dry Powder Inhaler (DPI) | 1 inhalation once daily |
Breztri is a metered-dose inhaler (MDI), which requires coordination between pressing the canister and inhaling—something to keep in mind if you have arthritis, tremors, or difficulty with hand strength.
Trelegy, on the other hand, uses the Ellipta DPI, which is breath-actuated. You simply open the cover, inhale deeply, and close the device—making it generally easier to use for most patients.
Dosing Frequency
Breztri: Two puffs once daily
Trelegy: One inhalation once daily
Both are convenient once-daily options, but Trelegy may be easier for those who prefer a single step.
Side Effects Comparison
| Common Side Effects | Breztri | Trelegy |
|---|---|---|
| Oral thrush | Yes | Yes |
| Cough or hoarseness | Yes | Yes |
| Increased heart rate | Yes | Yes |
| Headache or dizziness | Yes | Yes |
| Diarrhea or GI upset | Slightly more common | Less common |
Both medications can cause oral thrush, so patients should rinse their mouth after use. Some people report more digestive upset with Breztri, likely due to formoterol, while others may feel a faster heartbeat or jitteriness with Trelegy.
If you experience persistent side effects, talk to your provider. Sometimes switching from one to the other resolves the problem.
Pricing: U.S. vs. Canada
In the U.S., both Breztri and Trelegy can cost over $500 per inhaler, depending on insurance coverage. Many patients pay out of pocket, especially if they’re under high-deductible plans or uninsured.
Here’s how prices compare when you order from Over the Border Meds:
| Inhaler | U.S. Price | Canada (via Over the Border Meds) |
|---|---|---|
| Breztri Aerosphere | ~$540 USD | ~$197 USD |
| Trelegy Ellipta | ~$550 USD | ~$189.95 USD |
How to Order Breztri or Trelegy from Canada
At Over the Border Meds, U.S. patients can access affordable medications through a trusted Canadian prescription referral service.
Here’s how to get started:
1. Visit OverTheBorderMeds.com
2. Search for “Breztri” or “Trelegy”
3. Upload your U.S. prescription
4. Select your medication and dosage
5. Get it shipped directly to your home—no insurance required
Use coupon code Hello10 for 10% off your first order.
Which Inhaler Is Right for You?
Choose Breztri if you:
Are comfortable with MDI inhalers
Have done well on budesonide or formoterol previously
Need a more cost-effective option through Canadian referral services
Choose Trelegy if you:
Prefer a dry powder inhaler
Want a one-step, one-inhalation device
Have had good results with fluticasone in the past
Ultimately, both medications are excellent choices for COPD. Your doctor may consider your past medication history, device preference, and how you tolerate each ingredient before recommending one.
Final Thoughts
Both Breztri Aerosphere and Trelegy Ellipta offer effective, once-daily triple therapy for patients managing COPD. While they differ in ingredients and device design, both are proven to reduce exacerbations and improve lung function over time.
For U.S. patients seeking a cost-effective way to access these medications, ordering from Canada through Over the Border Meds offers substantial savings—often more than $300 per month. And our team is always here to help with prescription support, shipping questions, or savings options.
📦 Learn more or place your order today at OverTheBorderMeds.com