Kerendia (Finerenone) Tablets From Canada

Kerendia (Finerenone) is an aldosterone antagonist used in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) to reduce the risk of kidney failure and cardiovascular events like heart attack, stroke, or hospitalization for heart failure. Kerendia works by blocking the effects of aldosterone, a hormone involved in blood pressure regulation, which helps reduce inflammation and fibrosis in the kidneys and heart.

How Kerendia Works

Kerendia blocks the mineralocorticoid receptor in the kidneys, preventing the binding of aldosterone. This mechanism helps reduce inflammation and fibrosis in tissues, leading to better blood pressure control and reduced kidney damage. It is particularly beneficial for patients with CKD and T2D by helping to preserve kidney function and lower the risk of cardiovascular complications.

Kerendia Dosage and Administration

Kerendia is available in 10 mg and 20 mg oral tablets. The recommended starting dose is based on the patient's estimated glomerular filtration rate (eGFR). If eGFR is between 25-60 mL/min/1.73 m², the starting dose is 10 mg daily, and for those with eGFR ≥60, the starting dose is 20 mg daily. Monitor potassium and eGFR levels regularly to adjust the dose as necessary.

Kerendia should be taken once daily with or without food, at the same time each day. Avoid grapefruit or grapefruit juice while taking Kerendia.

Possible Side Effects of Kerendia

Common side effects of Kerendia include:

• Hyperkalemia (high potassium levels)
• Decreased glomerular filtration rate (GFR)
• Hypotension (low blood pressure)

Serious but less common side effects include:

• Severe hyperkalemia leading to heart rhythm problems
• Allergic reactions (swelling, rash)

Contact your healthcare provider if you experience significant side effects or worsening symptoms.

Drug Interactions

Kerendia may interact with certain medications, including:

• Potassium-sparing diuretics
• ACE inhibitors or ARBs
• Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin)

Inform your healthcare provider about all medications you are taking to avoid interactions.

Precautions When Using Kerendia

Before starting Kerendia, inform your healthcare provider if you have:

• High potassium levels or kidney issues
• Liver disease
• Are pregnant, planning to become pregnant, or breastfeeding

Kerendia should be avoided in patients with Addison’s disease or those taking strong CYP3A4 inhibitors. Regular potassium monitoring is essential to avoid hyperkalemia.

Buying Kerendia from Canada

For U.S. patients, purchasing Kerendia from Canada can offer significant savings due to lower drug prices. Ensure that you buy from a licensed Canadian pharmacy and have a valid U.S. prescription. Always consult with your healthcare provider before purchasing medications internationally.

Storage Instructions for Kerendia

Store Kerendia tablets at room temperature, between 15°C and 30°C (59°F and 86°F). Keep the medication in its original packaging and out of reach of children. Avoid exposure to excessive heat and moisture.

Frequently Asked Questions (FAQs)

What is Kerendia used for?

Kerendia is used to reduce the risk of kidney failure and cardiovascular events in patients with chronic kidney disease and type 2 diabetes.

Can I buy Kerendia from Canada?

Yes, U.S. patients can buy Kerendia from licensed Canadian pharmacies. A valid prescription is required for the purchase.

How does Kerendia work?

Kerendia works by blocking the effects of aldosterone, which reduces inflammation and fibrosis in the kidneys and heart, leading to better kidney function and cardiovascular protection.

Kerendia is an effective treatment for patients with CKD and T2D, offering protection against kidney failure and cardiovascular risks. Purchasing Kerendia from a Canadian pharmacy can provide cost savings for U.S. patients. Always consult your healthcare provider before making any changes to your treatment plan.

For more detailed information, you can refer to the official product monograph here.