Rifaximin (Xifaxan/Zaxine) Tablets

What is Rifaximin?

Rifaximin is an antibiotic primarily used to treat travelers’ diarrhea caused by certain bacteria and irritable bowel syndrome (IBS) with diarrhea. In the U.S., it is commonly known under the brand name Xifaxan, while in Canada, it is available under the name Zaxine. Rifaximin works by stopping the growth of bacteria in the gut, helping to relieve symptoms of diarrhea and reduce the risk of complications in certain liver diseases, such as hepatic encephalopathy.

How Rifaximin Works

Rifaximin is a non-systemic antibiotic that targets the gut. It works by inhibiting bacterial RNA synthesis, preventing the growth and survival of bacteria responsible for certain gastrointestinal conditions. By acting locally in the intestines, Rifaximin treats bacterial infections with minimal absorption into the bloodstream, reducing the risk of systemic side effects while effectively managing conditions like travelers’ diarrhea, IBS with diarrhea, and hepatic encephalopathy.

Rifaximin Dosage and Administration

The dosage of Rifaximin depends on the condition being treated:

• Travelers’ Diarrhea: The typical dose is 200 mg taken orally three times daily for 3 days.
• Irritable Bowel Syndrome with Diarrhea (IBS-D): The usual dose is 550 mg taken orally three times daily for 14 days. Patients may repeat the treatment if symptoms return.
• Hepatic Encephalopathy: The dose for reducing the recurrence of hepatic encephalopathy is 550 mg twice daily.

Always follow your healthcare provider’s instructions and take Rifaximin at the same times each day. Complete the full course of treatment, even if symptoms improve before finishing the medication.

Possible Side Effects of Rifaximin

Common side effects of Rifaximin include:

• Nausea
• Headache
• Abdominal pain
• Fatigue
• Constipation

Serious side effects, though rare, may include:

• Severe allergic reactions (rash, swelling, difficulty breathing)
• Persistent or worsening diarrhea (which could indicate a more serious infection)
• Liver problems (yellowing of the skin or eyes, dark urine)

If you experience severe side effects or allergic reactions, contact your healthcare provider immediately.

Drug Interactions

Rifaximin has minimal drug interactions due to its low systemic absorption. However, inform your healthcare provider of all medications and supplements you are taking, particularly those used to treat liver disease or antibiotics, to avoid potential interactions.

Precautions When Using Rifaximin

Before starting Rifaximin, inform your healthcare provider if you:

• Have a history of liver disease
• Are pregnant or breastfeeding
• Have a history of allergic reactions to antibiotics

Rifaximin should not be used for infections caused by non-bacterial pathogens, such as viral or parasitic infections. It is also not recommended for patients with severe liver impairment unless directed by a healthcare provider.

Buying Rifaximin (Xifaxan/Zaxine) from Canada

For U.S. patients, purchasing Rifaximin from Canada under the brand name Zaxine can be a cost-effective option. Canadian pharmacies often offer lower prices for prescription medications compared to the U.S. Here's how U.S. patients can safely buy Rifaximin from Canada:

• Check Pharmacy Accreditation: Ensure the Canadian pharmacy is licensed and legitimate.
• Consult Your Doctor: Always discuss with your healthcare provider before buying medications from another country to confirm it is a safe option for you.
• Understand U.S. Import Regulations: The FDA allows patients to import up to a 90-day supply of medication for personal use.
• Valid Prescription: You will need a valid U.S. prescription to purchase Zaxine from Canada.

By purchasing Rifaximin from a licensed Canadian pharmacy, U.S. patients can access the same high-quality medication at a lower price, whether under the brand name Xifaxan or Zaxine.

Storage Instructions for Rifaximin

Store Rifaximin at room temperature (15°C to 30°C) in its original packaging. Keep it away from moisture and heat, and ensure that it is stored out of reach of children and pets.

Frequently Asked Questions (FAQs)

Is there a difference between Xifaxan and Zaxine?

Xifaxan and Zaxine are both brand names for Rifaximin. Xifaxan is the name used in the U.S., while Zaxine is the name used in Canada. Both medications contain the same active ingredient and are used to treat similar conditions.

Can I buy Zaxine from Canada without a prescription?

No, a prescription is required to purchase Zaxine (Rifaximin) from Canada. You can use a U.S. prescription to legally buy the medication from a licensed Canadian pharmacy.

How long should I take Rifaximin for IBS?

The typical course of Rifaximin for IBS with diarrhea is 14 days. If symptoms return, your healthcare provider may recommend repeating the treatment.

For more detailed information, you can refer to the official product monograph here.

Always take Xifaxan exactly as prescribed by your doctor. The dosage and length of treatment depend on the specific condition being treated. Xifaxan can be taken with or without food.