Pentasa (Mesalazine) Tablets From Canada

Pentasa (Mesalazine), also known as 5-aminosalicylic acid (5-ASA), is a medication used to treat mild to moderate ulcerative colitis and Crohn’s disease. It is an anti-inflammatory drug that works by reducing inflammation in the colon and rectum. Pentasa is available in extended-release tablets, rectal suspension (enema), and suppositories.

How Pentasa Works

Pentasa works by reducing inflammation in the intestines through the inhibition of certain substances (like prostaglandins and leukotrienes) that cause inflammation. This helps alleviate the symptoms associated with inflammatory bowel diseases (IBD), such as abdominal pain, diarrhea, and rectal bleeding.

Pentasa Dosage and Administration

Pentasa is available in the following forms:

• Tablets (500 mg, 1 g): The usual dosage for treating active ulcerative colitis or Crohn’s disease is 2 g to 4 g per day, divided into multiple doses. For maintenance therapy, a daily dose of 2 g is commonly prescribed.
• Enema (1 g or 4 g): The enema is typically administered once daily at bedtime for the treatment of ulcerative colitis affecting the distal part of the colon.
• Suppositories (1 g): Used for ulcerative proctitis, a suppository is administered once daily at bedtime.

Pentasa extended-release tablets should be taken with food and should not be crushed, chewed, or broken. Always follow your healthcare provider’s instructions on how to use Pentasa.

Possible Side Effects of Pentasa

Common side effects of Pentasa include:

• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Fatigue

Serious but rare side effects may include:

• Kidney problems (including kidney failure)
• Severe skin reactions (Stevens-Johnson syndrome)
• Liver problems
• Blood disorders (such as anemia or pancytopenia)
• Allergic reactions

If you experience any severe side effects, discontinue use and contact your healthcare provider immediately.

Drug Interactions

Pentasa may interact with other medications, especially those that affect kidney function. Inform your healthcare provider if you are taking NSAIDs (such as ibuprofen), azathioprine, or 6-mercaptopurine, as these medications may increase the risk of kidney damage when taken with Pentasa. Regular monitoring of kidney function may be necessary.

Buying Pentasa from Canada

For U.S. patients, purchasing Pentasa from Canada can be a cost-effective option due to the lower prices of prescription medications in Canada. However, it is important to ensure that you are buying from a legitimate online Canadian pharmacy to avoid counterfeit drugs.

Here are some tips for safely buying Pentasa from Canada:

• Check Pharmacy: Ensure the online Canadian pharmacy is licensed. Ask to speak to a pharmacist.
• Consult Your Doctor: Always talk to your healthcare provider before purchasing medications from another country to ensure it’s a safe and appropriate option for you.
• Understand U.S. Import Rules: The FDA typically allows a 90-day supply of medication to be imported for personal use.
• Valid Prescription: A valid U.S. prescription is required to purchase Pentasa from Canada.

Storage Instructions for Pentasa

Store Pentasa extended-release tablets at room temperature (between 15°C and 30°C) and protect them from light. Enemas and suppositories should be stored at controlled room temperature, preferably below 25°C. Keep Pentasa out of the reach of children.

Pentasa is an effective treatment for managing the symptoms of ulcerative colitis and Crohn’s disease. Always use Pentasa as directed by your healthcare provider and monitor for any side effects. If you are considering purchasing Pentasa from Canada, ensure that you are buying from a reputable source and consult with your healthcare provider to make an informed decision.

For more detailed information, you can refer to the official product monograph here.

Pentasa is usually taken orally, with or without food, as prescribed by your healthcare provider. Swallow the capsules whole without crushing or chewing them, and follow your doctor's instructions regarding the dosage and schedule to manage ulcerative colitis effectively.