Janumet (Sitagliptin and Metformin) Tablets From Canada

Janumet is a combination oral medication containing sitagliptin and metformin. It is used to help control blood sugar levels in adults with type 2 diabetes. Sitagliptin is a DPP-4 inhibitor, which increases insulin production after meals, while metformin is a biguanide that reduces glucose production in the liver and improves insulin sensitivity. Together, they provide more effective blood sugar control when diet and exercise alone are not enough.

How Janumet Works

Janumet combines two active ingredients: sitagliptin and metformin. Sitagliptin works by inhibiting the DPP-4 enzyme, which allows the body to produce more insulin when needed, particularly after meals. Metformin, on the other hand, reduces the amount of glucose produced by the liver and helps the body utilize insulin more effectively. This dual mechanism helps lower blood sugar levels and improves glycemic control in patients with type 2 diabetes.

Janumet Dosage and Administration

Janumet is available in three strengths: 50 mg/500 mg, 50 mg/850 mg, and 50 mg/1000 mg of sitagliptin/metformin. It is typically taken twice daily with meals to reduce the risk of gastrointestinal side effects from metformin. The dosage is individualized based on the patient’s current treatment, and it is important to follow your healthcare provider’s instructions carefully. The maximum recommended daily dose of sitagliptin is 100 mg, and the metformin dose should not exceed 2000 mg per day.

Patients should not split or crush the tablets, and it is essential to monitor blood sugar levels regularly to ensure that the treatment is effective. If a dose is missed, it should be taken as soon as remembered, but double doses should not be taken.

Possible Side Effects of Janumet

Common side effects of Janumet include:

• Nausea
• Diarrhea
• Upper respiratory infection
• Headache
• Stomach upset

Serious side effects may include lactic acidosis, a rare but potentially fatal complication associated with metformin. Symptoms of lactic acidosis include muscle pain, difficulty breathing, and unusual tiredness. Seek medical attention immediately if these symptoms occur. Other serious side effects include pancreatitis and severe allergic reactions. Contact your healthcare provider if you experience persistent symptoms or if your condition worsens.

Drug Interactions

Janumet may interact with certain medications, including:

• Diuretics
• ACE inhibitors
• Insulin or other antidiabetic drugs
• Medications that affect kidney function

Always inform your healthcare provider of all the medications you are taking to avoid potential interactions.

Precautions When Using Janumet

Before using Janumet, inform your healthcare provider if you:

• Have kidney or liver problems
• Have a history of heart failure
• Are pregnant or breastfeeding
• Have a history of lactic acidosis or other metabolic issues

Janumet should be used with caution in elderly patients and those with reduced kidney function due to the increased risk of metformin accumulation and lactic acidosis.

Buying Janumet from Canada

For U.S. patients, purchasing Janumet from Canada offers an affordable option compared to U.S. prices. Ensure that you purchase from a licensed Canadian pharmacy and have a valid U.S. prescription. It is important to consult your healthcare provider before making any changes to your diabetes management plan.

Storage Instructions for Janumet

Store Janumet tablets at room temperature, between 15°C and 30°C (59°F and 86°F). Keep the medication in its original container, away from moisture and heat. Ensure it is stored out of the reach of children and pets.

Frequently Asked Questions (FAQs)

What is Janumet used for?

Janumet is used to control blood sugar levels in adults with type 2 diabetes when diet and exercise are not enough. It is a combination of sitagliptin and metformin, which work together to improve glycemic control.

Can I buy Janumet from Canada?

Yes, you can purchase Janumet from Canada with a valid U.S. prescription. It is often more affordable to buy from licensed Canadian pharmacies compared to U.S. pharmacies.

How should I take Janumet?

Janumet should be taken twice daily with meals to reduce the risk of gastrointestinal upset. Follow your healthcare provider’s dosage instructions carefully, and do not split or crush the tablets.

Janumet offers effective blood sugar control for patients with type 2 diabetes. Buying Janumet from Canada can provide significant savings for U.S. patients. Always consult your healthcare provider before making any changes to your diabetes treatment plan.

For more detailed information, you can refer to the official product monograph here.