Akynzeo From Canada for U.S. Patients

What is Akynzeo?

Akynzeo is a combination medication containing netupitant and palonosetron, used to prevent nausea and vomiting caused by chemotherapy. Netupitant is a substance P/neurokinin 1 (NK1) receptor antagonist, while palonosetron is a 5-HT3 receptor antagonist. Together, these ingredients work to block the signals in the brain that trigger nausea and vomiting, providing comprehensive protection against both acute and delayed chemotherapy-induced nausea and vomiting.

How to Take Akynzeo

Akynzeo is taken as a single capsule approximately one hour before the start of chemotherapy. It is typically used in combination with dexamethasone, a corticosteroid that further helps to prevent nausea and vomiting. The recommended dose of Akynzeo is one capsule containing 300 mg of netupitant and 0.5 mg of palonosetron. The capsule should be swallowed whole, with or without food.

It is important to follow your doctor’s instructions carefully when taking Akynzeo. Do not take more than the prescribed dose, and do not take Akynzeo on days when you are not receiving chemotherapy, unless advised by your doctor.

What Does Akynzeo Look Like?

Akynzeo comes in the form of a hard gelatin capsule. The capsule is white with a caramel cap and has "HE1" printed on the body. Each capsule contains three tablets of netupitant and one capsule of palonosetron.

Possible Side Effects of Akynzeo

Like all medications, Akynzeo can cause side effects. The most common side effects include:

• Headache: This is one of the most frequently reported side effects.
• Constipation: Some patients may experience difficulty in bowel movements.
• Fatigue: Feeling unusually tired or weak.

Serious side effects, although rare, may include severe allergic reactions, QT prolongation (a heart rhythm condition), serotonin syndrome, or significant changes in blood pressure. If you experience any of these symptoms, seek medical attention immediately.

Serious Side Effects

While serious side effects are rare, they can occur. These include:

• QT Prolongation: A change in heart rhythm that can lead to serious conditions like torsade de pointes.
• Serotonin Syndrome: Symptoms include agitation, hallucinations, rapid heartbeat, and severe nausea or vomiting.
• Severe Allergic Reactions: Symptoms may include rash, itching, swelling, severe dizziness, or trouble breathing.

If you experience any of these side effects, contact your healthcare provider immediately.

Drug Interactions with Akynzeo

Akynzeo can interact with other medications, which may affect how it works or increase the risk of side effects. It’s important to tell your doctor about all the medications you are taking, including over-the-counter drugs, vitamins, and supplements. Some important interactions include:

• CYP3A4 Inhibitors: Drugs like ketoconazole can increase the levels of netupitant in your blood, leading to increased side effects.
• QT-Prolonging Drugs: Combining Akynzeo with other medications that prolong the QT interval can increase the risk of heart rhythm problems.
• Serotonergic Drugs: Using Akynzeo with drugs that affect serotonin levels, like SSRIs or SNRIs, can increase the risk of serotonin syndrome.

Buying Akynzeo from Canada

For U.S. patients, purchasing Akynzeo from Canada can be a cost-effective option due to the lower prices of prescription medications in Canada. However, it is important to ensure that you are buying from a legitimate online Canadian pharmacy to avoid counterfeit drugs.

Here are some tips for safely buying Akynzeo from Canada:

• Check Pharmacy: Ensure the online Canadian pharmacy is licensed. Ask to speak to a pharmacist.
• Consult Your Doctor: Always talk to your healthcare provider before purchasing medications from another country to ensure it’s a safe and appropriate option for you.
• Understand U.S. Import Rules: The FDA typically allows a 90-day supply of medication to be imported for personal use.
• Valid Prescription: You will need a valid U.S. prescription to purchase Akynzeo from a Canadian pharmacy.

While buying Akynzeo from Canada can save money, it’s important to proceed cautiously and under the guidance of your healthcare provider.

Important Considerations

Not for Everyone: Akynzeo should not be used by individuals who are allergic to netupitant, palonosetron, or any other ingredients in the medication. It is also not recommended for use during pregnancy or breastfeeding.

Pregnancy and Breastfeeding: Akynzeo is contraindicated during pregnancy and should not be used by women who are breastfeeding. Women of childbearing potential should use effective contraception during treatment and for one month after the last dose.

Final Thoughts

Akynzeo is an effective medication for preventing nausea and vomiting caused by chemotherapy. By following your doctor’s instructions and being aware of potential side effects and drug interactions, you can safely use Akynzeo to manage your symptoms and improve your quality of life during chemotherapy. If you are considering purchasing Akynzeo from Canada, ensure you are buying from a reputable source and consult with your healthcare provider to make an informed decision.

For more detailed information, you can refer to the official product monograph here.

Typically taken as a single dose, about 1 hour before the start of chemotherapy. Follow your healthcare provider’s instructions closely regarding dosage and frequency.