CagriSema vs Zepbound: Battleground for Diabetes and Obesity

CagriSema vs Zepbound: Battleground for Diabetes and Obesity

CagriSema vs Zepbound


CagriSema, a groundbreaking development by Novo Nordisk, is a once-weekly injection that combines two powerful components: semaglutide and cagrilintide. Semaglutide, known under brand names like Ozempic for diabetes and Wegovy for weight management, is already a familiar name in the medical community. Cagrilintide, on the other hand, mimics the hormone amylin, enhancing the feeling of fullness after meals. This unique combination is set to revolutionize the treatment of type 2 diabetes and obesity.


Clinical Trial Insights

In a recent phase 2 clinical trial, CagriSema demonstrated impressive results in managing type 2 diabetes. The trial, involving 92 adults, compared the effects of semaglutide, cagrilintide, and their combination (CagriSema). After 32 weeks, those treated with CagriSema experienced a significant A1C reduction of 2.2%, a 16% loss in body weight, and a 43% improvement in time in range.


Treatment Average Decrease in A1C (%) Participants with A1C ≤ 6.5% (%) Average Decrease in Body Weight (%)
CagriSema 2.2 75 15.6
Semaglutide 1.8 48 5.1
Cagrilintide 0.9 17 8.1
Comparison of the efficacy of each treatment in terms of reducing A1C levels and facilitating weight loss, both critical factors in managing type 2 diabetes and obesity.

Comparative Efficacy

When pitted against semaglutide and cagrilintide alone, CagriSema showed superior results in lowering A1C and promoting weight loss. A noteworthy 75% of CagriSema participants achieved an A1C level of 6.5% or lower, a significant improvement compared to 48% for semaglutide and 17% for cagrilintide alone.


Side Effects and Safety

CagriSema’s safety profile is encouraging, with gastrointestinal side effects like nausea or vomiting being the most common. Importantly, there were no severe instances of hypoglycemia reported, a crucial consideration for diabetes treatments.


CagriSema vs. Zepbound

With the recent FDA approval of Eli Lilly’s Zepbound (tirzepatide) for obesity, a new competitor has emerged. Novo Nordisk has launched a Phase III trial to compare CagriSema with Zepbound, particularly focusing on their efficacy in weight management. Early indications suggest that CagriSema might outperform Zepbound, even at its highest dose, in reducing body weight.


Patient Considerations

As a patient considering treatment options, it’s important to note that CagriSema is still in the research phase and not yet FDA-approved. Its potential benefits include significant improvements in A1C levels, weight loss, and blood sugar management. However, like all medications, it comes with possible side effects, primarily gastrointestinal.



CagriSema represents a significant advancement in the treatment of type 2 diabetes and obesity. Its once-weekly injection format and combination of two effective drugs make it a convenient and potent option. While it’s still undergoing clinical trials, its promising results offer hope for better management of these conditions. As always, patients should consult with their healthcare providers to discuss the most appropriate treatment options based on their individual health needs and the latest medical advancements.



Up-To-Date: semaglutide

PubMed: Efficacy and safety of co-administered once-weekly cagrilintide with semaglutide