What is Xerese?

Xerese is a prescription topical cream combining antiviral acyclovir (5%) and anti-inflammatory hydrocortisone (1%) designed to treat cold sores (herpes labialis) at their earliest onset in patients aged 6 and up. Used at the first signs—tingling, itching, or redness—it helps shorten healing time and reduce ulceration risks :contentReference[oaicite:0]{index=0}.

How Xerese Works

Acyclovir suppresses viral replication by inhibiting DNA synthesis, while hydrocortisone reduces redness, swelling, and discomfort. The synergistic action speeds lesion healing and improves comfort :contentReference[oaicite:1]{index=1}.

Indications and Usage

Xerese is specifically indicated for early cold sores on lips or around the mouth and should not be used on genitals, eyes, or other body parts :contentReference[oaicite:2]{index=2}. It is safe for ages 6 and older, though its safety profile for pregnant or breastfeeding women remains unclear :contentReference[oaicite:3]{index=3}.

Dosage & Application

• Apply a thin layer to affected area 5 times per day for 5 days at the first sign of a sore :contentReference[oaicite:4]{index=4}.
• Apply gently without rubbing or covering with bandages.
• Wash hands before and after use to prevent spread :contentReference[oaicite:5]{index=5}.

Side Effects & Precautions

Common local side effects include mild burning, tingling, redness, dryness, flaking, or changes in skin color. Allergic reactions like hives or swelling are rare but serious and must prompt medical attention :contentReference[oaicite:6]{index=6}. Avoid using on open wounds or with occlusive dressings.

Drug Interactions & Contraindications

Xerese is contraindicated in those allergic to acyclovir or hydrocortisone :contentReference[oaicite:7]{index=7}. It should be used cautiously in immunocompromised individuals, and simultaneous use with other topical medications (like sunscreens or lip products) is not recommended :contentReference[oaicite:8]{index=8}.

Storage Instructions

Store at room temperature between 20–25°C (68–77°F). Do not freeze. Keep in original packaging, away from light, and out of reach of children :contentReference[oaicite:9]{index=9}.

How Fast Does Xerese Work?

Applied early, Xerese can shorten the duration of sores and reduce progression to ulcerative lesions, often within days. However, full healing can take up to 2 weeks; consult a healthcare provider if no improvement is seen :contentReference[oaicite:10]{index=10}.

Comparing Xerese to Other Cold‑Sore Products

Unlike OTC acyclovir creams or docosanol products, Xerese uniquely combines antiviral and anti-inflammatory agents for more effective relief. Its prescription status ensures regulated quality and efficacy :contentReference[oaicite:11]{index=11}.

Why Buy Xerese from Canada?

U.S. patients can save significantly by purchasing Xerese from licensed Canadian pharmacies due to more affordable drug pricing. These pharmacies provide FDA-approved brand medication sourced from Canada :contentReference[oaicite:12]{index=12}.

Coupons & Savings

Order Xerese via Over The Border Meds and use coupon code hello10 to save 10% on your first order. Bulk purchase discounts may also be available.

How to Order Xerese from Canada

1. Obtain a valid U.S. prescription for Xerese.
2. Submit your prescription through Over The Border Meds.
3. Search for Xerese and complete your purchase.
4. Receive your medication securely to your U.S. address while saving significantly.